Results 51 to 60 of about 6,625 (139)

A guide to reactive oxygen species in tumour hypoxia: measurement and therapeutic implications

open access: yesMolecular Oncology, Volume 19, Issue 11, Page 3003-3022, November 2025.
Hypoxia reshapes tumour redox landscapes by altering compartmental ROS production (mitochondria, NOX, ER, peroxisomes). Accurate interpretation requires oxygen‐contextualised measurement (live biosensors, chemical probes, EPR, LC–MS) and awareness of artefacts (reoxygenation, probe specificity).
Lina Hacker   +3 more
wiley   +1 more source

Cobalamin‐Dependent Aryl Methyl Ether O‐Demethylases: Promising Enzymes for Biocatalytic Applications from Lignin Valorization to Organic Synthesis

open access: yesChemCatChem, Volume 17, Issue 21, November 10, 2025.
Cobalamin‐dependent aryl methyl ether O‐demethylases have high potential for biocatalytic applications, including lignin valorization and synthetic chemistry. In this review, we provide a detailed overview of such O‐demethylase systems identified to date from various microorganisms, including their mechanism, substrate scope and selectivity, and ...
Niels Krabbe Johnsen   +4 more
wiley   +1 more source

Reaction of Papaverine with Baran DiversinatesTM

open access: yesMolecules, 2019
The reaction of papaverine with a series of Baran DiversinatesTM is reported. Although the yields were low, it was possible to synthesize a small biodiscovery library using this plant alkaloid as a scaffold for late-stage C−H functionalization. Ten
Folake A. Egbewande   +3 more
doaj   +1 more source

Cyanide Beyond Toxicity: A Systematic Review of Its Effects on Vascular Function

open access: yesBasic &Clinical Pharmacology &Toxicology, Volume 137, Issue 5, November 2025.
ABSTRACT Cyanide is widely recognized for its potent toxicity, yet evidence shows that concentrations below 1 μM may enhance cytochrome c oxidase activity and have a regulatory function. Recent findings also demonstrate that mammalian cells, including endothelial cells, produce cyanide endogenously, where it can modulate mitochondrial bioenergetics ...
Elif Alan‐Albayrak, Ulf Simonsen
wiley   +1 more source

Papaverine attenuates the progression of alpha naphthylisothiocyanate induce cholestasis in rats

open access: yesCurrent Research in Pharmacology and Drug Discovery
Cholestasis is a hepatobiliary condition that manifests as acute or chronic and results from disruptions in the bile flow, formation, or secretion processes.
Doaa Adnan Atshan, Munaf Hashim Zalzala
doaj   +1 more source

Efficacy of Papaverine to Prevent Radial Artery Spasm During Transradial Cerebral Angiography (PASS): rationale and design

open access: yesStroke and Vascular Neurology
Rationale Radial artery spasm (RAS) is a common complication during transradial cerebral angiography (TRA), but currently, the optimal prevention strategy is not well established. Papaverine has anti-vasospasm, sedative and analgesic effects.
Jingwen Yang   +10 more
doaj   +1 more source

Effect of papaverine hydrochloride solution on survival rate of neural-island flap in experiment

open access: yesБюллетень сибирской медицины, 2010
The neural-island flap is based only on a nerve and survives by intra-and extraneural vessels. Effect of a 2% solution of a papaverine on survival rate of neural-island flap was studied in research. The predominating role of a nerve in survival rate of a
A. V. Baytinger, A. A. Yezhov
doaj   +1 more source

Structure-Based Design, Synthesis, Biological Evaluation, and Molecular Docking of Novel PDE10 Inhibitors With Antioxidant Activities

open access: yesFrontiers in Chemistry, 2018
Phosphodiesterase 10 is a promising target for the treatment of a series of central nervous system (CNS) diseases. Imbalance between oxidative stress and antioxidant defense systems as a universal condition in neurodegenerative disorders is widely ...
Jinxuan Li   +6 more
doaj   +1 more source

Investigating the anticancer and synergistic effects of the combination of green synthesized silver nanoparticles and papaverine on breast cancer cell lines: focusing on the apoptosis pathway and microRNA regulation

open access: yesArtificial Cells, Nanomedicine, and Biotechnology
The study investigates the anticancer effects of green silver nanoparticles (Ag-NPs) synthesized from Viola cornuta extract combined with papaverine on breast cancer cells.
Maryam Fekri Soufiabadi   +2 more
doaj   +1 more source

Relations among alkaloids, cadmium and zinc contents in opium poppy (Papaver somniferum L.)

open access: yesPlant, Soil and Environment, 2006
The effort of this work was to prove whether there exists any relation between stress factors caused by content of cadmium and zinc, and content and composition of opium alkaloids codeine, morphine, narcotine (noscapine) and papaverine contained in poppy
J. Lachman   +4 more
doaj   +1 more source

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