Results 61 to 70 of about 75,135 (288)

miR-191 downregulation plays a role in thyroid follicular tumors through CDK6 targeting [PDF]

, 2010
miR-191 expression is frequently altered in several neoplasias, being upregulated in some, such as pancreatic, colon, lung and prostate carinomas, and downregulated in others, such as severe medulloblastomas and melanomas.
Colamaio, Marianna
core  

MiR-886-3p regulates cell proliferation and migration, and is dysregulated in familial non-medullary thyroid cancer. [PDF]

PLoS ONE, 2011
The molecular basis and characteristics of familial non-medullary thyroid cancer are poorly understood. In this study, we performed microRNA (miRNA) profiling of familial and sporadic papillary thyroid cancer tumor samples.Genome wide miRNA profiling of ...
Yin Xiong, Lisa Zhang, Alisha K Holloway, Xiaolin Wu, Ling Su, Electron Kebebew   +5 more
doaj   +1 more source

Local recurrence of papillary thyroid cancer [PDF]

Expert Review of Endocrinology & Metabolism, 2015
Management of advanced papillary thyroid cancer (PTC >10 mm) is changing its focus. Mortality was the main outcome measure for patients treated before the 90s. In the past two decades, however, most patients diagnosed with PTC belong to the very low risk of death group.
openaire   +2 more sources

Malectin Alleviates Endoplasmic Reticulum Stress in Gestational Diabetes Mellitus via Glycoprotein Quality Control Mechanisms

Advanced Science, EarlyView.
Malectin alleviates high glucose‐induced ER stress and damage in placental trophoblasts, a function dependent on its six critical carbohydrate‐binding residues. In a GDM mouse model, administration of TAT‐Malectin ameliorated hyperglycemia and placental ER stress and prevented fetal macrosomia.
Jiahui Zhu, Yumeng Zhang, Ye Wang, Xiaoyu Zhu, Ailin Yuan, Weijing Yin, Huangmin Yu, Xuemin Pang, Yufeng He, Yuchen Wang, Tong Wang, Yong Li, Yunlong Si   +12 more
wiley   +1 more source

“The potential role of CXCR4 and SDF-1 as indicators of tumor aggressiviness in patients with conventional papillary thyroid carcinoma” [PDF]

, 2008
Background: Functional chemokine receptors are expressed in many malignant tumors, including papillary thyroid carcinoma (PTC). These receptors promote tumor growth and metastasis in response to endogenous chemokines.
Pagano, Loredana
core  

Postnatal Expression of BRAFV600E Does Not Induce Thyroid Cancer in Mouse Models of Thyroid Papillary Carcinoma [PDF]

, 2013
The mutant BRAF (BRAFV600E) is the most common genetic alteration in papillary thyroid carcinomas (PTCs). The oncogenicity of this mutation has been shown by some genetically engineered mouse models.
Nakashima, Masahiro, Kondo, Shinji, Taguchi, Ryo, Kimura, Shioko, Shimamura, Mika, Yamada, Masanobu, Nagayama, Yuji, Nakahara, Mami, Orim, Florence, Kurashige, Tomomi, Mitsutake, Norisato   +10 more
core   +2 more sources

Modulation of Lung Adenocarcinoma by Phosphorylated FOXN3‐Mediated Transcriptional Inactivation of p53

Advanced Science, EarlyView.
In non‐tumorous lung tissues, FOXN3 promotes the transcriptional activation of p53 by facilitating its recruitment to target promoters, thereby suppressing lung tumorigenesis through activation of the p53 signaling pathway. Conversely, in lung adenocarcinoma tissues, hyperphosphorylated FOXN3 dissociates from the promoters of p53‐responsive genes and ...
Jinjin Yu, Jingyu Yu, Suhui Wang, Xinghong Hu, Lele Jin, Nan Wu, Yuhan Ni, Xueying Zhang, Chengling Zhao, Jihong Zhou, Yong Zhang, Baofa Sun, Hongxing Zhang, Chunfu Zheng, Song Guo Zheng, Wei Li, Xinxing Zhu   +16 more
wiley   +1 more source

Biological function of Cl 2 gene and it’s role in thyroid cancer [PDF]

, 2011
Here I report data to support a tumor suppressor role of the Cl 2 gene. Indeed, I detected a drastic reduction, of Cl 2 gene expression in almost all thyroid carcinomas analyzed, with respect to normal thyroid, with the lowest expression levels observed ...
Ferraro, Angelo
core  

Role of Interleukin-18 in Thyroid tumorigenesis [PDF]

, 2016
Purpose: Although the significance of Interleukin-18 (IL-18) has been studied in pathogenesis of different cancers including, ovarian, gastric, breast, lung carcinoma and melanoma, its role in thyroid cancer- the most common endocrine malignancy has not ...
Gajjar, Kinjal; Division of Molecular Endocrinology, Department of Cancer Biology, The Gujarat Cancer & Research Institute (GCRI), Ahmedabad-380 016, India, Kobawala, Toral; Division of Molecular Endocrinology, Department of Cancer Biology, The Gujarat Cancer & Research Institute (GCRI), Ahmedabad-380 016, India, Patel, Girish; Division of Molecular Endocrinology, Department of Cancer Biology, The Gujarat Cancer & Research Institute (GCRI), Ahmedabad-380 016, India, Ghosh, Nandita; Division of Molecular Endocrinology, Department of Cancer Biology, The Gujarat Cancer & Research Institute (GCRI), Ahmedabad-380 016, India, Trivedi, Trupti; Division of Molecular Endocrinology, Department of Cancer Biology, The Gujarat Cancer & Research Institute (GCRI), Ahmedabad-380 016, India   +4 more
core   +1 more source

Posthumously Diagnosed Myhre Syndrome Presenting With Pleural Remodeling and Endometrial Cancer

American Journal of Medical Genetics Part C: Seminars in Medical Genetics, EarlyView.
ABSTRACT Myhre syndrome (OMIM 139210) is a genetic condition defined by neurodevelopmental disability, characteristic facial features, and multisystem proliferative fibrosis. While various types of lung disease have been reported, pleural remodeling leading to restrictive lung disease has not yet been described.
Jeanette Saffir, Karee Morgan, Karigynn Chaimson, Blake E. Funke, Kim L. Sandler, Melissa Hogan, Thomas Cassini   +6 more
wiley   +1 more source