Results 51 to 60 of about 19,247 (199)

Cytokine‐Engineered Chimeric Antigen Receptor‐T Cell Therapy: How to Balance the Efficacy and Toxicity

open access: yesAdvanced Science, Volume 13, Issue 14, 9 March 2026.
Cytokine‐engineered CAR‐T cells represent a promising immunotherapy against malignancies due to direct tumor killing and potent immunity response. However, significant toxicities, including CRS and ICANS, have restricted clinical applications. How to keep the risk‐benefit balance of the advanced therapy is of great importance for maximizing the benefit
Xinru Zhang   +7 more
wiley   +1 more source

A Case of Multiple Sclerosis Presenting as Eight and Half Syndrome. [PDF]

open access: yes, 2013
Multiple sclerosis (MS) is a chronic disease characterized by inflammation, demyelination, gliosis (scarring), and neuronal loss; the course can be relapsing-remitting or progressive.
Kaushik, M   +4 more
core  

Unilateral optic neuropathy following subdural hematoma: a case report [PDF]

open access: yes, 2010
Introduction Unilateral optic neuropathy is commonly due to a prechiasmatic affliction of the anterior visual pathway, while losses in visual hemifields result from the damage to brain hemispheres.
Alexandra Kretz   +22 more
core   +1 more source

A Case of Knobloch Syndrome With Lens Dislocation Resembling Homocystinuria

open access: yesClinical Case Reports, Volume 14, Issue 3, March 2026.
ABSTRACT We report a 39‐year‐old woman with lifelong visual impairment who presented in June 2024 with progressive visual deterioration in her right eye. Ophthalmologic evaluation revealed severe high myopia, vitreoretinal degeneration, phthisis bulbi of the left eye, and downward lens dislocation of the right eye.
Elnaz Asadollahzadeh   +4 more
wiley   +1 more source

How Far Can we Go? Managing Moyamoya Syndrome in a 3‐Year‐Old With Thalassemia Major: A Rare Pediatric Case From Nepal

open access: yesClinical Case Reports, Volume 14, Issue 3, March 2026.
ABSTRACT Moyamoya syndrome (MMS) is a rare progressive cerebrovascular disorder causing stenosis of intracranial arteries and collateral vessel formation. Pediatric presentations often include ischemic strokes, and coexisting Thalassemia Major may worsen vascular outcomes.
Kshitiz Parajuli   +8 more
wiley   +1 more source

Unilateral Papilledema with Bilateral Optic Nerve Sheath Distension: A Case Report

open access: yesTürk Oftalmoloji Dergisi
Bilateral edematous optic disc swelling from papilledema is caused by elevated intracranial pressure (ICP). Idiopathic intracranial hypertension (IIH), a clinical syndrome with elevated ICP of unclear etiology, is a frequent cause of this condition.
Raghda Shawky El-Gendy   +4 more
doaj   +1 more source

Papilloedema [PDF]

open access: yes, 1979
Papilledema is one of the causes of reduction or loss of visual acuity. Fora better understanding of this abnormality,the nor- mal anatomy of the optic disk is briefly described followed by the possible causes of papilledema and the changes observed ...
Soeroso, Admadi
core  

Elevated cerebral spinal fluid biomarkers in children with mucopolysaccharidosis I-H. [PDF]

open access: yes, 2016
Mucopolysaccharidosis (MPS) type-IH is a lysosomal storage disease that results from mutations in the IDUA gene causing the accumulation of glycosaminoglycans (GAGs).
Dickson, Patricia I   +6 more
core   +1 more source

Glymphatic System Dysfunction in Central Nervous System Diseases

open access: yesCNS Neuroscience &Therapeutics, Volume 32, Issue 3, March 2026.
Glymphatic Dysfunction in Neurological Disorders: The glymphatic system is a brain‐wide clearance system that removes neurotoxic waste via AQP4‐mediated CSF‐ISF exchange. Dysfunction through AQP4 mislocalization, BBB injury, and inflammation annihilates clearance and causes acute (stroke, TBI) and chronic disease.
Anwar Zahran   +14 more
wiley   +1 more source

The diagnostic challenge of evaluating papilledema in the pediatric patient

open access: yesTaiwan Journal of Ophthalmology, 2017
Pseudopapilledema is a fairly common finding in ophthalmic practice, and in many cases, the diagnosis is straightforward. However, an accurate diagnosis can challenge the most seasoned clinicians, and missing true papilledema can result in life ...
Brandon McCafferty   +2 more
doaj   +1 more source

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