Results 51 to 60 of about 175,854 (316)

The Mus musculus Papillomavirus Type 1 E7 Protein Binds to the Retinoblastoma Tumor Suppressor: Implications for Viral Pathogenesis

mBio, 2021
The species specificity of papillomaviruses has been a significant roadblock for performing in vivo pathogenesis studies in common model organisms. The Mus musculus papillomavirus type 1 (MmuPV1) causes cutaneous papillomas that can progress to squamous ...
Tao Wei, Miranda Grace, Aayushi Uberoi, James C. Romero-Masters, Denis Lee, Paul F. Lambert, Karl Munger   +6 more
doaj   +1 more source

Self‐Assembly of Antigenic Peptide Nanofibrils Templates the Growth of Silica Nanoparticles for Nanovaccines

Advanced Science, EarlyView.
Antigenic peptides Aβ42 and E7 self‐assemble into nanofibrils; APTES and TEOS induce SiO2 NP formation on these fibrils to form SiO2@fibril nanovaccines, which activate BMDCs in vitro. In vivo, SiO2@Aβ42 fibril nanovaccines alleviate AD symptoms and clear Aβ42 plaques in APP/PS1 mice, and SiO2@E7 fibril nanovaccines inhibit tumor growth and promote ...
Xuecheng Yang, Min Li, Zhiying Yao, Yu Hu, Zhili Wang, Wendi Shi, Bingbing Sun   +6 more
wiley   +1 more source

Altered Nasal Microbiota in Sinonasal Tumors: A Comparative Analysis of Malignant and Benign Sinonasal Tumors

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Although shifts in nasal microbiota have been well‐documented in inflammatory upper airway conditions, microbiota tumor‐associated alterations remain uncharacterized. This study is the first to compare sinonasal microbiota profiles of patients with malignant tumors (MT), benign tumors (BT), and controls, offering insights into tumor‐
Evan A. Patel, Phillip A. Engen, Glen D. Souza, Sarah Khalife, Donyea Moore, Lauren Kret, Pedro Escobedo, Stefan J. Green, Ankur Naqib, Peter Filip, Peter Papagiannopoulos, Bobby A. Tajudeen, Mahboobeh Mahdavinia, Pete S. Batra   +13 more
wiley   +1 more source

Human papillomavirus vaccines [PDF]

Canadian Medical Association Journal, 2017
Human papillomavirus is the most common sexually transmitted infection. Persistent infection with a high-risk HPV type causes virtually all cases of cervical cancer and has been associated with 90% of anal, 70% of vaginal, 40% of vulvar and 65% of penile cancers,[1][1] as well as up to 70 ...
Shainoor J, Ismail, Shelley L, Deeks
openaire   +2 more sources

The COPII Transport Complex Participates in HPV16 Infection

Viruses
Human papillomavirus (HPV) 16 is transported in a retrograde fashion from the cell surface to the Golgi apparatus. Prior to mitosis, the virus loses association with the Golgi and, following nuclear envelope breakdown, is found associated with the ...
Patricia M. Day, Cynthia D. Thompson, Andrea S. Weisberg, John T. Schiller   +3 more
doaj   +1 more source

Human Papillomavirus Vaccines

Reviews in Medical Virology, 2006
AbstractA wealth of epidemiological and molecular evidence has led to the conclusion that virtually all cases of cervical cancer and its precursor intra‐epithelial lesions are a result of infection with one or other of a subset of genital human papillomaviruses (HPVs) suggesting that prevention of infection by prophylactic vaccination would be an ...
europepmc   +4 more sources

Plant Virus Immunotherapy for HPV‐Associated Oropharyngeal Squamous Cell Carcinoma

Advanced NanoBiomed Research, EarlyView.
Cowpea mosaic virus (CPMV) nanoparticles are safe and potent cancer immunotherapy candidates with strong immunomodulatory activity. CPMV activates innate immunity, which in turn drives adaptive immune responses and promotes durable, systemic antitumor effects.
Jessica Fernanda Affonso de Oliveira, Patrick Opdensteinen, Andrea Simms, Seongwon Jung, Giuliana P. Mognol, Hui Chen, Judith A. Varner, Nicole F. Steinmetz   +7 more
wiley   +1 more source

Detection and genotyping of human Papillomavirus in urine samples from unvaccinated male and female adolescents in Italy [PDF]

, 2013
The introduction of vaccination against Human Papillomavirus (HPV) in adolescent girls in 2006 has focused virological surveillance on this age group. As few studies have evaluated HPV infections in young populations, further data are needed in order to ...
Zotti, CM, Boccalini, Sara, Elisabetta Tanzi, Gasparini Roberto, Coppola Rosa Cristina, R. Gasparini, Rosa Cristina Coppola, Coppola, RC, Gasparini R, Paolo Castiglia, M. Martinelli, M. Martinese, Panatto D, Silvia Bianchi, Amicizia, D, Amicizia D, Paolo Bonanni, Zotti CM, Elena Rosanna Frati, Bianchi S, Bianchi, S, Martinelli, M, Castiglia Paolo, Bianchi Silvia, D. Panatto, Marianna Martinelli, Meloni, Angelo, Tanzi Elisabetta, Amicizia, Daniela, G. Masia, Masia Giuseppina, Zotti, Carla Maria, Bianchi, Silvia, Daniela Amicizia, Bonanni, Paolo, Martinese M, Martinese, M, Masia G, Castiglia, Paolo Giuseppino, Tanzi, Elisabetta, S. Bianchi, Morena Martinese, C. M. Zotti, P. Castiglia, Coppola R C, Boccalini, S, Amicizia Daniela, Boccalini S, Martinelli Marianna, Bonanni Paolo, Bonanni P, Panatto, Donatella, Panatto Donatella, Frati, ER, Tanzi E, Zotti Carla Maria, Martinelli, Marianna, Frati ER, Piana Andrea, Tanzi, E., Piana A, Martinese, Morena, Gasparini, Roberto, Gasparini, R, Castiglia P, Donatella Panatto, Meloni Angelo, Martinese Morena, Sara Boccalini, D. Amicizia, E. Tanzi, Andrea Piana, P. Bonanni, Panatto, D, Meloni, A, Frati, Elena Rosanna, Masia, Giuseppina, Piana, Andrea Fausto, Boccalini Sara, Giuseppina Masia, R. C. Coppola, A. Meloni, E.R. Frati, Angelo Meloni, S. Boccalini, Roberto Gasparini, Frati Elena Rosanna, Masia, G, A. Piana, Martinelli M, Coppola, Rosa Cristina, Meloni A, Carla Maria Zotti, Bonanni, P   +93 more
core   +1 more source

Disulfide Bond–Modified Proteomics Reveals the Effects of Riboflavin on Protein Folding Dynamics

Animal Research and One Health, EarlyView.
Riboflavin deficiency impairs oxidative protein folding, causing ER misfolded protein accumulation, CHOP activation, and apoptosis, revealing a role of riboflavin in proteostasis. ABSTRACT Riboflavin is a crucial micronutrient essential for maintaining cellular homeostasis, acting as an important precursor for flavoproteins that utilize flavin ...
Bo Zhang, Shuisheng Hou, Jing Tang
wiley   +1 more source

A Novel In Vivo Infection Model To Study Papillomavirus-Mediated Disease of the Female Reproductive Tract

mBio, 2019
Papillomaviruses exhibit species-specific tropism, thereby limiting understanding and research of several aspects of HPV infection and carcinogenesis.
Megan E. Spurgeon, Aayushi Uberoi, Stephanie M. McGregor, Tao Wei, Ella Ward-Shaw, Paul F. Lambert   +5 more
doaj   +1 more source