Results 191 to 200 of about 16,162 (223)

Roles of E6 and E7 Human Papillomavirus Proteins in Molecular Pathogenesis of Cervical Cancer

Current Protein and Peptide Science, 2019
Human papillomavirus (HPV) cancers are expected to be major global health concerns in the upcoming decades. The growth of HPV-positive cancer cells depends on the consistent expression of oncoprotein which has been poorly taken into account in the cellular communication.
Eskandar Taghizadeh, Daryoush Rostami, Forough Taheri   +2 more
exaly   +3 more sources

Human Papillomavirus E6 and E7: Proteins which deregulate the cell cycle

BioEssays, 1995
AbstractNumerous clinical, epidemiological and molecular findings link some types of Human Papillomaviruses (HPV) with cancer of the genital tract. They share a common pathway of transformation with a number of DNA tumour viruses, such as Adenovirus and SV40.
M, Tommasino, L, Crawford
openaire   +2 more sources

Genus specific features of bovine papillomavirus E6, E7, E5 and E8 proteins

Virus Research, 2007
Six bovine papillomavirus (BPV) types, BPV-1 to -6, have been classified in genera Delta-papillomavirus (BPV-1 and -2), Epsilon-papillomavirus (BPV-5) and Xi-papillomavirus (BPV-3, -4 and -6). In addition, 16 unclassified putative BPV types have been reported.
Hiroshi Shirasawa
exaly   +3 more sources

Human papillomavirus type 77 E7 protein is a weak deregulator of cell cycle

Cancer Letters, 2007
Human Papillomavirus type 77 is a skin type found in non-melanoma skin cancers of immuno-compromised individuals. Although, the HPV77 E6 oncoprotein has been well studied, nothing is known about E7. Studies on mucosal HPV types (e.g. HPV16) showed that E7 deregulates the cell cycle by binding to and promoting degradation of retinoblastoma protein (pRb).
Mansour Mariam, Touka Majid, Malena Adriana, INDIVERI, Cesare, Dong Wen, Gionfriddo Ilaria, Accardi Rosita, Paradiso Angelo, Sylla Bakary S., Gabet Anne Sophie, Tommasino Massimo   +10 more
openaire   +2 more sources

Bacterial Expression and Immunological Detection of Human Papillomavirus Type 16 E7 Protein

Biochemical and Biophysical Research Communications, 1996
We have expressed an unfused E7 protein from human papillomavirus 16 into Escherichia coli by using a T7-RNA polymerase system. E7 mRNA was detected one hour after promoter induction. Western blot analysis using either a murine monoclonal antibody elicited against E7 or sera from cervical carcinoma patients demonstrated that recombinant E7 expressed in
A, Moro, P, Hernández
openaire   +2 more sources

Immune responses induced by BCG recombinant for human papillomavirus L1 and E7 proteins

Vaccine, 2000
Recombinant bacille Calmette-Guerin (BCG) based vaccine delivery systems could potentially share the safety and effectiveness of BCG. We therefore prepared recombinant BCG vaccines which expressed the L1 late protein of the human papillomavirus (HPV) 6b or the E7 early protein of the HPV 16. The two recombinants were evaluated as immunogens in C57BL/6J
Abdul Jabbar, I., Fernando, G. J., Saunders, N. A., Aldovini, A., Young, R., Malcolm, K. M., Frazer, I. H.   +6 more
openaire   +5 more sources

Association of RNA with Human Papillomavirus E7 Protein of Type 16 But Not Type 6b

Biochemical and Biophysical Research Communications, 1993
Nonfused human papillomavirus (HPV) type 16 and 6b E7 proteins were expressed in E. coli and fractionated by ion exchange and gel filtration chromatography. The E7 protein of type 6b was purified, but that of type 16 was found to be associated with RNA molecules which could not be excluded by repeated chromatography.
M, Chinami, K, Moriyama, Y, Fukumaki, M, Terada, M, Shingu   +4 more
openaire   +2 more sources

Intrinsic Disorder in the human papillomavirus E7 protein

2012
Fil: Sánchez Miguel, Ignacio Enrique. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química Biológica de la Facultad
Chemes, Lucia Beatriz, Sánchez Miguel, Ignacio Enrique, Alonso, Leonardo Gabriel, de Prat Gay, Gonzalo   +3 more
openaire   +1 more source

Targeted degradation of the retinoblastoma protein by human papillomavirus E7-E6 fusion proteins.

The EMBO Journal, 1992
The E6 and the E7 proteins of the oncogenic human papillomavirus types 16 and 18 can stably associate with p53 and the retinoblastoma protein, respectively. The E6-p53 interaction results in the accelerated degradation of p53 in vitro via the ubiquitin-dependent proteolysis system.
M, Scheffner, K, Münger, J M, Huibregtse, P M, Howley   +3 more
openaire   +2 more sources

Synthesis, phosphorylation, and nuclear localization of human papillomavirus E7 protein in Schizo-saccharomyces pombe

Gene, 1990
The complete E7 protein-encoding open reading frame of human papillomavirus type 16 (HPV-16) was expressed in the fission yeast Schizosaccharomyces pombe, under the control of a cloned yeast promoter. The HPV-16 E7 protein synthesized in S. pombe is a 17-kDa phosphoprotein which is recognized by anti-E7 antibodies (raised in rabbits against E7 fusion ...
Tommasino M., Contorni M., Scarlato V., Bugnoli M., Maundrell K., Cavalieri F.   +5 more
openaire   +3 more sources