Results 201 to 210 of about 93,899 (311)

Targeting Orexin 2 Receptors in Idiopathic Hypersomnia and Narcolepsy: A Randomised Phase 1b Proof‐Of‐Concept Study of Alixorexton

Journal of Sleep Research, EarlyView.
Orexin 2 receptor agonists have demonstrated that targeting the orexin system may address symptoms of central disorders of hypersomnolence. Results of this phase 1 study support the phase 2 clinical evaluation of oral alixorexton in patients with IH, NT2 and NT1.
Ronald R. Grunstein, Brendon J. Yee, Julia L. Chapman, Jian Eu Tai, Sheila Sivam, Craig Hopkinson, Daniel G. Smith, Alexandra Lovett, Shifang Liu, Sergey Yagoda, Bhaskar Rege   +10 more
wiley   +1 more source

Development of Co and Cu-based metal-organic frameworks for electrochemical sensing of Pb ions and paracetamol. [PDF]

Nanoscale Adv
Akter F, Khan S, Islam S, Chowdhury AMS, Ahmed S, Kabir SF, Sahadat Hossain M.   +6 more
europepmc   +1 more source

Temporal Associations Between Physiological Sleep and Next‐Day Pain Intensity in Individuals With Activity‐Limiting Chronic Pain: A Multiple Night At‐Home Ear‐EEG Sleep‐Monitoring Study

Journal of Sleep Research, EarlyView.
ABSTRACT Chronic pain and sleep disturbances frequently co‐occur. However, most prior research relies on self‐report or actigraphy, which reflect behavioural aspects of sleep but provide only limited insight into the underlying sleep physiology. In this pre‐registered prospective observational study (NCT06368531), we investigated within‐person night‐to‐
Henrik Bjarke Vaegter, Nannapas Banluesombatkul, Maria Louise Stage Olsen, Kübra Kilic, Mia Dyhr Thomsen, Martin Christian Hemmsen, Preben Kidmose, Jonas Bloch Thorlund   +7 more
wiley   +1 more source

Fabrication and Optimization of 3D-Printed TiO₂/g‑C₃N₄ Scaffolds for Degradation of Organic Dye and Pharmaceutical Pollutant. [PDF]

ACS Omega
Soe HY, Na Wichean T, Panomsuwan G, Jongprateep O, Techapiesancharoenkij R.   +4 more
europepmc   +1 more source

Pharmacogenomics in Dentistry: From CYP‐Mediated Drug Response to Precision Prescribing in Oral Healthcare

Oral Diseases, EarlyView.
ABSTRACT Objective This narrative review critically assesses the clinical relevance of pharmacogenomics within dental genomics, distinguishing clinically actionable applications from emerging or investigational findings. Materials and Methods A targeted literature review was conducted in PubMed/MEDLINE, Scopus and Embase for publications from January ...
Giorgia Pieretto, Jessica Cusato, Martina Sansavini, Christian Bacci   +3 more
wiley   +1 more source

Quantifying the Equine Pain Response to Paracetamol Administration in Horses With Chronic Lameness Already Receiving Non-Steroidal Anti-Inflammatories. [PDF]

Vet Med Sci
Conduit S, Bowen M, Bailey J, Redpath A.
europepmc   +1 more source

Can Knee Arthroscopy Be Considered Entirely Safe for Patients Over 50 Years Old With no Risk of Osteonecrosis? Case Series and Literature Review on Post‐Artrhoscopy Osteonecrosis of the Knee (PAONK)

Orthopaedic Surgery, Volume 17, Issue 5, Page 1378-1388, May 2025.
Post‐arthroscopy osteonecrosis is a rare complication occurring in 0.82% of cases, primarily affecting patients over 50 with degenerative meniscal tears. Early detection through MRI and conservative treatment, including bisphosphonates and weight‐bearing avoidance, proved effective in most cases, while some required surgical intervention.
Panagiotis Ntagiopoulos, Georgios Kalinterakis, Pierrenzo Pozzi, Dimitris Fligkos, George Themistocleous, Sotirios Themistokleous, Triantafyllia Dimou, Riccardo Compagnoni, Paolo Ferrua, Pietro Simone Randelli   +9 more
wiley   +1 more source

Periodontal considerations during orthodontic intrusion and extrusion in healthy and reduced periodontium

Periodontology 2000, EarlyView.
Abstract In patients with advanced periodontal disease, pathological tooth migration may occur, which may require subsequent orthodontic treatment for both aesthetic and functional purposes. When planning orthodontic treatment mechanics, intrusive or extrusive forces are frequently indicated.
Gregory S. Antonarakis, Alkisti Zekeridou, Stavros Kiliaridis, Catherine Giannopoulou   +3 more
wiley   +1 more source

Effectiveness of prophylactic administration of intravenous paracetamol for prevention of post-spinal anesthesia shivering among parturients undergoing cesarean section at a tertiary specialized hospital: a prospective cohort study, 2025. [PDF]

Ann Med Surg (Lond)
Teklewold MG, Muzien SJ, Awol MA, Desta TD.   +3 more
europepmc   +1 more source

The efficacy of biologic factors on the surgical therapy of periodontal suprabony defects: A systematic review and network meta‐analysis of randomized clinical trials

Periodontology 2000, EarlyView.
Abstract Objectives This systematic review investigated the efficacy of biologic factors in the surgical treatment of periodontal suprabony defects. Materials and Methods Three databases were searched to identify RCTs comparing open‐flap debridement (OFD) combined with biologic factors only, or combined with bone substitute, and/or barriers to the same
Carrie Chew, Nikolaos Donos, Stefano Corbella, Isabella Manso, Greta Castellini, Elena Calciolari   +5 more
wiley   +1 more source