Results 81 to 90 of about 10,332 (185)

A Phase 1 Dose‐Escalation, Food Effect, and Drug–Drug Interaction Study Evaluating the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of the MALT1 Inhibitor, SGR‐1505, in Healthy Volunteers

Clinical Pharmacology in Drug Development, Volume 15, Issue 1, January 2026.
Abstract SGR‐1505 is a novel small‐molecule inhibitor of MALT1, a key mediator of NF‐κB signaling implicated in the pathogenesis of B‐cell malignancies. This study evaluated the safety, tolerability, pharmacokinetics, and pharmacodynamics of SGR‐1505 in healthy volunteers. In this four‐part, open‐label study, 73 participants received single or multiple
Vipul K. Gupta, Brian Yoo, Daniel Weiss, Frank G. Basile, Edgar Schuck, Christopher M. Rubino, Sen Zhang, Stephen E. Maxwell, Wenxin Zheng, Joanne B. L. Tan, David Stenehjem, Paul B. Watkins, Margaret Dugan, Wu Yin, D. Hamish Wright, Karen Akinsanya, Jason Lickliter   +16 more
wiley   +1 more source

Patterns and trends of medicinal poisoning substances: a population-based cohort study of injuries in 0–11 year old children from 1998–2018

Archives of Public Health
Background There have been sharp increases in antidepressant and opioid prescriptions over the last 10 years, as well as increased over-the-counter medicine availability.
Edward G Tyrrell, Elizabeth Orton, Laila J Tata, Denise Kendrick   +3 more
doaj   +1 more source

Paracetamol-induced liver injury modelled in Xenopus laevis embryos [PDF]

, 2019
Introduction: Failure to predict drug-induced liver injury (DILI) remains a major contributing factor to lead compound drop-out during drug development. Xenopus embryos are amenable for early stage medium throughput small molecule screens and so have the
Saide, Katy, Sherwood, Victoria, Wheeler, Grant N.   +2 more
core   +3 more sources

Six-year follow-up of impact of co-proxamol withdrawal in England and Wales on prescribing and deaths: time-series study.

PLoS Medicine, 2012
BackgroundThe analgesic co-proxamol (paracetamol/dextropropoxyphene combination) has been widely involved in fatal poisoning. Concerns about its safety/effectiveness profile and widespread use for suicidal poisoning prompted its withdrawal in the UK in ...
Keith Hawton, Helen Bergen, Sue Simkin, Claudia Wells, Navneet Kapur, David Gunnell   +5 more
doaj   +1 more source

Animal poisonings in Belgium: a review of the past decade [PDF]

, 2010
This review focuses on poisonings in companion animals, including horses, farm animals and wildlife, investigated and recorded during the past ten years at the Laboratory of Toxicology of the Faculty of Veterinary Medicine (Ghent University) and the ...
Croubels, Siska, De Backer, Patrick, Van Pelt, Henk, Vandenbroucke, Virginie   +3 more
core   +1 more source

Characteristics of non-fatal self-poisoning in Sri Lanka: A systematic review

, 2016
Background The rate of non-fatal self-poisoning in Sri Lanka has increased in recent years, with associated morbidity and economic cost to the country. This review examines the published literature for the characteristics and factors associated with non-
Christensen, Helen, Griffiths, Kathleen M, Rajapakse, Thilini   +2 more
core   +1 more source

Drug Hepatotoxicity: Environmental Factors [PDF]

, 2017
Drug-induced liver injury presents as various forms of acute and chronic liver disease. There is wide geographic variation in the most commonly implicated agents.
Chalasani, Naga P., Stine, Jonathan G.
core   +1 more source

Patterns and outcomes of paracetamol poisoning management in Hamad Medical Corporation, Qatar: A retrospective cohort study. [PDF]

Medicine (Baltimore), 2023
Abushanab D, Gasim M, Devi D, Elbdairy M, Elqasass H, Ahmed N, Vincent M, Abdul Rouf PV, Mohammed HR, Hail MA, Thomas B, Elkassem W, Hanssens Y, Elgassim M, Elmoheen A, Azad A, Mohammed S, Salem W.   +17 more
europepmc   +1 more source

Antidote use in a pediatric emergency department [PDF]

, 2014
INTRODUCTION: Poisoning is an infrequent cause of consultation in a pediatric emergency department (PED), but it can be potentially serious. Pediatricians should know how to use the available antidotes properly.
Almario Hernández, AF, Escuredo Argullós, L, Luaces Cubells, C, Martínez Sánchez, L, Mação, P, Trenchs Sainz de la Maza, V   +5 more
core  

GUIDELINES FOR PARACETAMOL POISONING TREATMENT

Zdravniški Vestnik, 2014
Paracetamol overdose results in an accumulation of the reactive, hepatotoxic metabolite N-acetyl-p-benzoquinoneimin (NAPKQI) which can cause serious liver injury. Recognition of paracetamol overdose, hepatotoxicity risk estimation and early treatment are
Lucija Sarc, Marija Jamsek, Damjan Grenc, Miran Brvar   +3 more
doaj