Results 61 to 70 of about 13,399 (247)

Expressed sequence tag analysis of the human pathogen Paracoccidioides brasiliensis yeast phase: Identification of putative homologues of Candida albicans virulence and pathogenicity genes [PDF]

, 2003
Paracoccidioides brasiliensis, a thermodimorphic fungus, is the causative agent of the prevalent systemic mycosis in Latin America, paracoccidioidomycosis. We present here a survey of expressed genes in the yeast pathogenic phase of P. brasiliensis.
Batista, Wagner L. [UNIFESP], Bernardes, Luciano Angelo de Souza, Bogossian, Ana Paula, Ferreira, Leslie Ecker., Goldman, Gustavo H., Goldman, Maria Helena S, Marques, Everaldo dos Reis, Moreira, Julio C., Nobrega, Francisco G., Nobrega, Marina Pasetto, Nunes, Luiz R., Oliveira, Regina C. de, Puccia, Rosana [UNIFESP], Quiapin, Andrea Carla, Ribeiro, Diogenes Custodio Duarte, Savoldi, Marcela, Semighini, Camile P., Tekaia, Fredj, Travassos, Luiz R. [UNIFESP], Vitorelli, Patricia Marostica   +19 more
core   +1 more source

Silica Nanoparticles as Multifunctional Platforms for Vaccine Delivery and Immune Modulation in Infectious Diseases

Advanced NanoBiomed Research, Volume 5, Issue 12, December 2025.
Overview of the use of silica nanoparticles in vaccines against pathogens. Different kinds of vaccines against infectious diseases are currently using solid or mesoporous silica nanoparticles in their formulation. Silica microparticles and nanoparticles (SiNPs) have been studied as vehicles for vaccines.
Noe Juvenal Mendoza‐Ramírez, Julio García‐Cordero, Gabriela Navarro‐Tovar, Leticia Cedillo‐Barrón   +3 more
wiley   +1 more source

Identification of human plasma proteins associated with the cell wall of the pathogenic fungus Paracoccidioides brasiliensis [PDF]

, 2013
Paracoccidioides brasiliensis and Paracoccidioides lutzii are thermodimorphic species that cause paracoccidioidomycosis. the cell wall is the outermost fungal organelle to form an interface with the host.
Almeida, Igor C., Ganiko, Luciane, Longo, Larissa V. G., Matsuo, Alisson L., Nakayasu, Ernesto S., Puccia, Rosana, Silva, Roberta Peres da, Sobreira, Tiago J. P., Vallejo, Milene C.   +8 more
core   +2 more sources

Integrated In Silico – In Vitro Study Investigating Dipeptides as Chorismate Synthase Modulators: Spotlight on Its Mechanism of Action

Global Challenges, Volume 9, Issue 12, December 2025.
This study integrates computational and experimental approaches to explore how short dipeptides modulate the activity of chorismate synthase. Unexpectedly, the GluAsp dipeptide enhanced enzyme activity by promoting a transient surface channel near the active site, possibly revealing a new structural feature relevant for microbial metabolism and ...
Lorenzo Pedroni, Katharina Fuchs, Gianni Galaverna, Peter Macheroux, Luca Dellafiora   +4 more
wiley   +1 more source

Clinical and Eco-Epidemiological Aspects of a Novel Hyperendemic Area of Paracoccidioidomycosis in the Tocantins-Araguaia Basin (Northern Brazil), Caused by Paracoccidioides sp.

Journal of Fungi, 2022
Paracoccidioidomycosis (PCM) is the most prevalent systemic mycosis in Brazil. The disease is caused by dimorphic fungi nested within the Paracoccidioides genus.
Alessandra G. Krakhecke-Teixeira, Danielle H. Yamauchi, Alexsandra Rossi, Herdson R. de Sousa, Hans G. Garces, Joaquim L. Júnior, Antônio O. S. Júnior, Maria Sueli S. Felipe, Eduardo Bagagli, Heitor F. de Andrade, Marcus de M. Teixeira   +10 more
doaj   +1 more source

Variable gp43 secretion by Paracoccidioides brasiliensis clones obtained by two different culture methods [PDF]

, 2005
The main objectives of this study were to obtain clones of Paracoccidioides brasiliensis by two methods (micromanipulation and plating assay) and to determine if the secretion of the 43-kDa glycoprotein (gp43) is dependent on the clonal culture.
Berzaghi, Rodrigo, Camargo, Zoilo Pires de, Silva, Silvia Helena M da   +2 more
core   +3 more sources

Flagellins as Vaccine Adjuvants and Cancer Immunotherapy: Recent Advances and Future Prospects

Immunology, Volume 176, Issue 3, Page 277-303, November 2025.
The figure depicts the role of flagellin in immune cells. Flagellin interacts with TLR5, resulting in the formation of homodimers and the recruitment of MyD88, which activates the IκB and MAPK signalling pathways. This results in the activation of NF‐κB and AP‐1, producing TNF‐α, IL‐6, IL‐8, and IL‐12.
Asma Talukder, Md. Mijanur Rahman, Md. Sifat Rahi, Dean L. Pountney, Ming Q. Wei   +4 more
wiley   +1 more source

Detection of the basement membrane-degrading proteolytic activity of Paracoccidioides brasiliensis after SDS-PAGE using agarose overlays containing Abz-MKALTLQ-EDDnp [PDF]

, 1999
We have characterized, in the Paracoccidioides brasiliensis yeast phase, an exocellular SH-dependent serine proteinase activity against Abz-MKRLTL-EDDnp and analogous fluorescent-quenched peptides, and showed that it is also active against constituents ...
Carmona, Adriana Karaoglanovic, Juliano, Luiz, Juliano, Maria Aparecida, Puccia, Rosana, Travassos, Luiz Rodolpho   +4 more
core   +4 more sources

Extracellular Vesicles From Fungal Infection in Humans: A Key Player in Immunological Responses

Journal of Extracellular Biology, Volume 4, Issue 8, August 2025.
ABSTRACT Fungal infections cause approximately 1.6 million deaths annually. Diagnosing and treating fungal infections is difficult due to limited access to diagnostic tests and rising antifungal resistance. Extracellular vesicles (EVs) facilitate interactions between fungal cells and hosts, significantly influencing the pathogen‐host relationship ...
Caroline P. de Rezende, Patrick W. S. Santos, Renan A. Piraine, Virgínia C. Silvestrini, Julio C. J. Barbosa, Fabiana C. P. Valera, Edwin Tamashiro, Guilherme G. Podolski‐Gondim, Silvana M. Quintana, Rodrigo Calado, Roberto Martinez, Taicia P. Fill, Márcio L. Rodrigues, Fausto Almeida   +13 more
wiley   +1 more source

A hidden battle in the dirt: Soil amoebae interactions with Paracoccidioides spp.

PLoS Neglected Tropical Diseases, 2019
Paracoccidioides spp. are thermodimorphic fungi that cause a neglected tropical disease (paracoccidioidomycosis) that is endemic to Latin America. These fungi inhabit the soil, where they live as saprophytes with no need for a mammalian host to complete ...
Patrícia Albuquerque, André Moraes Nicola, Diogo Almeida Gomes Magnabosco, Lorena da Silveira Derengowski, Luana Soares Crisóstomo, Luciano Costa Gomes Xavier, Stefânia de Oliveira Frazão, Fernanda Guilhelmelli, Marco Antônio de Oliveira, Jhones do Nascimento Dias, Fabián Andrés Hurtado, Marcus de Melo Teixeira, Allan Jefferson Guimarães, Hugo Costa Paes, Eduardo Bagagli, Maria Sueli Soares Felipe, Arturo Casadevall, Ildinete Silva-Pereira   +17 more
doaj   +1 more source