Results 61 to 70 of about 4,442 (176)
Advanced NanoBiomed Research, Volume 5, Issue 12, December 2025.Overview of the use of silica nanoparticles in vaccines against pathogens. Different kinds of vaccines against infectious diseases are currently using solid or mesoporous silica nanoparticles in their formulation. Silica microparticles and nanoparticles (SiNPs) have been studied as vehicles for vaccines.
Noe Juvenal Mendoza‐Ramírez +3 more
wiley +1 more source
Innate immunity to Paracoccidioides brasiliensis infection [PDF]
Mycopathologia, 2008 Innate immunity is based in pre-existing elements of the immune system that directly interact with all types of microbes leading to their destruction or growth inhibition. Several elements of this early defense mechanism act in concert to control initial pathogen growth and have profound effect on the adaptative immune response that further develops ...
Vera Lúcia Garcia, Calich +8 more
openaire +2 more sources
Global Challenges, Volume 9, Issue 12, December 2025.This study integrates computational and experimental approaches to explore how short dipeptides modulate the activity of chorismate synthase. Unexpectedly, the GluAsp dipeptide enhanced enzyme activity by promoting a transient surface channel near the active site, possibly revealing a new structural feature relevant for microbial metabolism and ...
Lorenzo Pedroni +4 more
wiley +1 more source
Fungal DNA‐barcoding on a chip: Magnetoresistive biosensors for yeast infection diagnosis
VIEW, Volume 6, Issue 6, December 2025.The development of a fungal pathogen identification chip is herein demonstrated. Hybridization dynamics were tested against 58 species in silico and 4 species on chip. 95% accuracy, 91% sensitivity, 98% specificity and femtomolar limit of detection were achieved. Future perspectives include the integration of sample pre‐treatment modules.
Maria Zolotareva +8 more
wiley +1 more source
NLRP3 Inflammasome Activation by Paracoccidioides brasiliensis
PLoS Neglected Tropical Diseases, 2013 Paracoccidioides brasiliensis is the etiologic agent of paracoccidioidomycosis (PCM), the most prevalent systemic mycosis that is geographically confined to Latin America. The pro-inflammatory cytokine IL-1β that is mainly derived from the activation of the cytoplasmic multiprotein complex inflammasome is an essential host factor against opportunistic ...
Tavares, Aldo Henrique Fonseca Pacheco +5 more
openaire +5 more sources
Flagellins as Vaccine Adjuvants and Cancer Immunotherapy: Recent Advances and Future Prospects
Immunology, Volume 176, Issue 3, Page 277-303, November 2025.The figure depicts the role of flagellin in immune cells. Flagellin interacts with TLR5, resulting in the formation of homodimers and the recruitment of MyD88, which activates the IκB and MAPK signalling pathways. This results in the activation of NF‐κB and AP‐1, producing TNF‐α, IL‐6, IL‐8, and IL‐12.
Asma Talukder +4 more
wiley +1 more source
Extracellular Vesicles From Fungal Infection in Humans: A Key Player in Immunological Responses
Journal of Extracellular Biology, Volume 4, Issue 8, August 2025.ABSTRACT Fungal infections cause approximately 1.6 million deaths annually. Diagnosing and treating fungal infections is difficult due to limited access to diagnostic tests and rising antifungal resistance. Extracellular vesicles (EVs) facilitate interactions between fungal cells and hosts, significantly influencing the pathogen‐host relationship ...
Caroline P. de Rezende +13 more
wiley +1 more source
Species boundaries in the human pathogen Paracoccidioides
Fungal Genetics and Biology, 2017 The use of molecular taxonomy for identifying recently diverged species has transformed the study of speciation in fungi. The pathogenic fungus Paracoccidioides spp has been hypothesized to be composed of five phylogenetic species, four of which compose the brasiliensis species complex.
David A, Turissini +4 more
openaire +2 more sources
Climate Change, Natural Disasters, and Cutaneous Fungal Infections
International Journal of Dermatology, Volume 64, Issue 8, Page 1349-1355, August 2025.ABSTRACT Fungal infections are an important source of morbidity and mortality that can manifest as superficial or invasive diseases. Diagnostic techniques for human fungal pathogens remain problematic, and multi‐drug resistance is emerging. This review addresses the potential emergence of new fungal pathogens in changing environments and reported ...
Aditya K. Gupta +2 more
wiley +1 more source
PLoS Neglected Tropical Diseases, 2019 BackgroundThe genus Paracoccidioides consists of thermodymorphic fungi responsible for Paracoccidioidomycosis (PCM), a systemic mycosis that has been registered to affect ~10 million people in Latin America.
David Aciole Barbosa +9 more
doaj +1 more source