Results 61 to 70 of about 4,451 (178)

Melatonin Is Bound to a Glycolytic Protein Complex via Tdh2p During Fermentation in Saccharomyces cerevisiae

Journal of Pineal Research, Volume 78, Issue 2, March 2026.
ABSTRACT Melatonin (MEL) is a multifunctional bioactive compound known for its antioxidant properties and regulatory roles in both animal and microbial systems. Although MEL has been shown to interact with glycolytic enzymes in yeast, the molecular basis and physiological relevance of these interactions remain unclear.
Sandra Martín‐Esteban, Joseph J. Rossi, Cristobal A. Onetto, Antonio G. Cordente, María‐Jesús Torija, Gemma Beltran   +5 more
wiley   +1 more source

Antifungal Potential of Essential Oil Chemotypes of Eugenia uniflora Against Phytopathogens

Chemistry &Biodiversity, Volume 23, Issue 2, February 2026.
This study investigates the chemical profile and antifungal activity of Eugenia uniflora essential oils. The major constituents identified were selina‐1,3,7(11)‐trien‐8‐one and curzerene. The oils showed significant inhibitory effects against the phytopathogens Colletotrichum gloeosporioides and Pestalotia sp. These results emphasize the potential of E.
Ygor Nunes Moreira, Eduardo Barros Duarte‐Junior, Igor Sampaio Fontes, Elisabeth Alves Duarte Pereira de Medeiros, Camila da Silva Barbosa Pereira, Diego da Paixão Alves, Durval Reis Mariano‐Junior, Rosana Santos Cavalcante, Pedro Corrêa Damasceno‐Junior, André Marques dos Santos, Marco Andre Alves de Souza   +10 more
wiley   +1 more source

Neglected Mycoses in Brazil: A Population‐Based Study of Mortality and In‐Hospital Mortality Over 25 Years

Mycoses, Volume 69, Issue 2, February 2026.
ABSTRACT Objective To describe the epidemiology, associated factors, spatial distribution, and temporal trends of mortality and in‐hospital mortality related to systemic mycoses in Brazil, 2000–2024. Methods This is a nationwide ecological study combining temporal and spatial analyses using death certificates (DC; underlying and/or associated causes ...
Anderson Fuentes Ferreira, Jorg Heukelbach, Eliana Amorim de Souza, Maria Aparecida Shikanai‐Yasuda, Lisandra Serra Damasceno, Fernanda Dockhorn Costa, Terezinha do Menino Jesus Silva Leitão, Helia Kawa, Alberto Novaes Ramos Jr.   +8 more
wiley   +1 more source

Infrared Spectroscopy as a Promising Tool for Diagnosing and Typing Human Pathogenic Fungi

Mycoses, Volume 69, Issue 1, January 2026.
ABSTRACT Fungal infections are increasingly recognised as a global health challenge, responsible for millions of cases annually and substantial mortality, especially in immunocompromised individuals. Yet, the diagnosis of these infections remains notoriously difficult, often delayed by slow culture‐based methods or hindered by the high cost and ...
Anthony G. J. Medeiros, Ayrton L. F. Nascimento, Luana Rossato, Daniel Assis Santos, Nalu Teixeira de Aguiar Peres, Reginaldo Goncalves de Lima Neto, Jacques F. Meis, Kássio M. G. Lima, Rafael Wesley Bastos   +8 more
wiley   +1 more source

NLRP3 Inflammasome Activation by Paracoccidioides brasiliensis

PLoS Neglected Tropical Diseases, 2013
Paracoccidioides brasiliensis is the etiologic agent of paracoccidioidomycosis (PCM), the most prevalent systemic mycosis that is geographically confined to Latin America. The pro-inflammatory cytokine IL-1β that is mainly derived from the activation of the cytoplasmic multiprotein complex inflammasome is an essential host factor against opportunistic ...
Tavares, Aldo Henrique Fonseca Pacheco, Magalhães, Kelly Grace, Almeida, Raquel Das Neves, Correa, Rafael, Burgel, Pedro Henrique, Bocca, Anamélia Lorenzetti   +5 more
openaire   +5 more sources

Silica Nanoparticles as Multifunctional Platforms for Vaccine Delivery and Immune Modulation in Infectious Diseases

Advanced NanoBiomed Research, Volume 5, Issue 12, December 2025.
Overview of the use of silica nanoparticles in vaccines against pathogens. Different kinds of vaccines against infectious diseases are currently using solid or mesoporous silica nanoparticles in their formulation. Silica microparticles and nanoparticles (SiNPs) have been studied as vehicles for vaccines.
Noe Juvenal Mendoza‐Ramírez, Julio García‐Cordero, Gabriela Navarro‐Tovar, Leticia Cedillo‐Barrón   +3 more
wiley   +1 more source

Integrated In Silico – In Vitro Study Investigating Dipeptides as Chorismate Synthase Modulators: Spotlight on Its Mechanism of Action

Global Challenges, Volume 9, Issue 12, December 2025.
This study integrates computational and experimental approaches to explore how short dipeptides modulate the activity of chorismate synthase. Unexpectedly, the GluAsp dipeptide enhanced enzyme activity by promoting a transient surface channel near the active site, possibly revealing a new structural feature relevant for microbial metabolism and ...
Lorenzo Pedroni, Katharina Fuchs, Gianni Galaverna, Peter Macheroux, Luca Dellafiora   +4 more
wiley   +1 more source

ParaDB: A manually curated database containing genomic annotation for the human pathogenic fungi Paracoccidioides spp.

PLoS Neglected Tropical Diseases, 2019
BackgroundThe genus Paracoccidioides consists of thermodymorphic fungi responsible for Paracoccidioidomycosis (PCM), a systemic mycosis that has been registered to affect ~10 million people in Latin America.
David Aciole Barbosa, Fabiano Bezerra Menegidio, Valquíria Campos Alencar, Rafael S Gonçalves, Juliana de Fátima Santos Silva, Renata Ozelami Vilas Boas, Yara Natércia Lima Faustino de Maria, Daniela Leite Jabes, Regina Costa de Oliveira, Luiz R Nunes   +9 more
doaj   +1 more source

Destructive genital and oral ulcers in rural patients

JAAD Case Reports, 2021
Eduardo Mastrangelo Marinho Falcão, MD, MS, Priscila Marques de Macedo, MD, PhD, Dayvison Francis Saraiva Freitas, MD, PhD, Ziadir Francisco Coutinho, MD, PhD, Leonardo Pereira Quintella, MD, PhD, Rodrigo Almeida-Paes, PhD, Rosely Maria Zancopé-Oliveira, PhD, Antonio Carlos Francesconi do Valle, MD PhD   +7 more
doaj   +1 more source

Species boundaries in the human pathogen Paracoccidioides

Fungal Genetics and Biology, 2017
The use of molecular taxonomy for identifying recently diverged species has transformed the study of speciation in fungi. The pathogenic fungus Paracoccidioides spp has been hypothesized to be composed of five phylogenetic species, four of which compose the brasiliensis species complex.
David A, Turissini, Oscar M, Gomez, Marcus M, Teixeira, Juan G, McEwen, Daniel R, Matute   +4 more
openaire   +2 more sources