Results 31 to 40 of about 1,188,380 (318)

The anticipatory paradigm

open access: yesAI Magazine, 2023
AbstractAnticipatory thinking is necessary for managing risk in the safety‐ and mission‐critical domains where AI systems are being deployed. We analyze the intersection of anticipatory thinking, the optimization paradigm, and metaforesight to advance our understanding of AI systems and their adaptive capabilities when encountering low‐likelihood/high ...
Adam Amos-Binks   +2 more
openaire   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Decentralized Ledger Journalism: An Uninvestigated Frontier of Data-Driven Reporting

open access: yesRUDN Journal of Studies in Literature and Journalism
Proposes are offered Decentralized Ledger Journalism (DLJ) as a distinct and timely subfield within data journalism, emerging at the intersection of technological innovation and investigative practice.
Alexandra G. Shilina
doaj   +1 more source

THE GROUNDS OF KNOWLEDGE: A COMPARISON BETWEEN KUHN’S PARADIGMS AND FOUCAULT’S EPISTEMES

open access: yesKriterion, 2021
Thomas Kuhn’s “paradigms” and Michel Foucault’s “epistemes” are often seen as similar concepts, in that both would establish necessary conditions of knowledge. However, how close are they to each other?
Paulo Pirozelli
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Integal futures based on the paradigm approach

open access: yes, 2013
The study discusses the interpretation of integral futures in the context of paradigm. The dynamic matrix model of futures paradigm has been developed for carrying out meta-analysis of futures.
Hideg, Éva
core   +1 more source

A review on the extreme rainfall studies in India

open access: yesNatural Hazards Research
Climate vulnerability in the Indian region becomes a major concern due to the frequent hydro-meteorological extreme events throughout the year. The number of extreme rainfall events (ERE) associated with monsoon, thunderstorms and short-spanned local ...
Payoshni Samantray   +1 more
doaj   +1 more source

Observed and model‐simulated thermodynamic processes associated with urban heavy rainfall events over Bangalore, India

open access: yesMeteorological Applications, 2020
A total of 32 rainfall events spanning the period from 2012 to 2014 over the urban Indian city of Bangalore were simulated using the Weather Research and Forecast (WRF) model.
P. Ajilesh   +3 more
doaj   +1 more source

Alternatives for sustained disaster risk reduction: A re-assessment

open access: yesJàmbá, 2023
Alternatives for sustained disaster risk reduction’ was published in 2010 by Francophone and Anglophone researchers as a critique on the way disasters were studied and disaster risk reduction handled in the Francophone sphere.
Loic Le De   +8 more
doaj   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

open access: yesFEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas   +3 more
wiley   +1 more source

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