Results 51 to 60 of about 1,546,652 (311)
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
At-turas: Jurnal Studi Keislaman, 2023 This research is based on the gap between the theory of religious conflict and the reality of the religious transition paradigm currently. Media issues have warmed up again lately with some news about the policy of disbanding radical mass organizations ...
Rif'an Humaidi +2 more
doaj +1 more source
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
Contemporary patterns of transatlantic trade cooperation in a post-Brexit European Union (dis)order [PDF]
CES Working Papers, 2020 This paper aims to examine the debate surrounding negotiations of the Transatlantic Trade and Investment Partnership (TTIP). The EU and US began negotiations for this comprehensive commercial agreement in July 2013 and have still not reached consensus ...
Iulia-Anamaria GHIDIU
doaj +2 more sources
Shifting paradigms: A critical pragmatic evaluation of key factors affecting learner-empowered emergent technology integration [PDF]
, 2018 This dissertation used a critical pragmatic research paradigm, transformative mixed methods research methodology, and a paradigm shift framework to explore online graduate level students’ perceptions of what key government, institutional, curricular ...
Wark, Norine
core
, 2013 AIMS: Although the focus of therapeutic intervention has been on neurohormonal pathways thought to be harmful in heart failure (HF), such as the renin-angiotensin-aldosterone system (RAAS), potentially beneficial counter-regulatory systems are also ...
Rouleau J +13 more
core +1 more source
FEBS Letters, EarlyView.Synechocystis strains deficient in succinate dehydrogenase (SDH) secrete more succinate than the WT under dark anaerobic conditions, supporting that SDH then primarily acts as SDH, not as a fumarate reductase. L‐aspartate oxidase (Laspo) from Synechocystis is functional under anaerobic conditions, reducing fumarate to succinate.
Kateryna Kukil +3 more
wiley +1 more source
A new paradigm for classifying and treating HER2‐positive breast cancer
Cancer Reports, 2023 Background Because of the phenomenal success of treatment with monoclonal antibodies and antibody‐drug conjugates targeting human epidermal growth factor receptor 2 (HER2), most patients with early‐stage HER2‐positive breast cancer (HER2+ BC) and some ...
Xuexin He +2 more
doaj +1 more source
Amid growing concerns over sustainable development failures, scholars are exploring the ‘regenerative paradigm’ as a pathway for systemic change; yet, its paradigmatic foundations remain underexamined. Using thematic analysis, we analyse the regenerative
Becken, Susanne +2 more
core +1 more source
Artificial molecular machines and motors—Design and control of nanoscale motion
FEBS Letters, EarlyView.Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley +1 more source