Results 71 to 80 of about 1,546,652 (311)

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Validation of the formulation of location quotient methods using regression analysis

Journal of Economic Structures
The location quotient (LQ) method, a widely used nonsurvey method, has been improved through a series of empirical studies, resulting in variations that incorporate various factors. These variations include the simple LQ (SLQ) method, which considers the
Mizuki Uchida
doaj   +1 more source

APOBEC3 activity and DNA polymerase‐ε deficiency are associated with distinct IDH1 R132 hotspot mutations

Molecular Oncology, EarlyView.
Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler, Bilal A. Lone, Ecem Unal, A. Rouf Banday   +3 more
wiley   +1 more source

Short- and Long-Term Effects of Undernutrition During Adolescence on Oxidative Status and Glucose Homeostasis in Male and Female Rats

Biology
Malnutrition during adolescence can cause metabolic diseases later in life. This study examined the short- and long-term effects of undernutrition during adolescence on body composition, glucose homeostasis and redox balance. Male (n = 32) and female (n =
Joskame Saint Paul, Antônio José Rocha Ribeiro, Ana Caroline Schoenberger Kipper, Mariele de Oliveira Souza, Thiara Chaves dos Santos, Karoline Paiva da Silva, Aline Milena Dantas Rodrigues, Manoela Fontenele Antunes, Isabelle Zanata Fabiane, Ana Júlia Lopes Braga Ferneda, Valéria Dornelles Gindri Sinhorin, Renata de Azevedo Melo Luvizotto, Júlio Cezar de Oliveira   +12 more
doaj   +1 more source

Improved Positive Predictive Performance of Listeria Indicator Broth: A Sensitive Environmental Screening Test to Identify Presumptively Positive Swab Samples

Microorganisms, 2019
PDX-LIB, Listeria Indicator Broth, was developed as a proprietary sensitive screening test to identify presumptively positive environmental swab samples for Listeria sp.
Alan D. Olstein, Joellen M. Feirtag
doaj   +1 more source

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

Elicitation of paradigm of 'give'

, 2016
Tyler Utt eliciting the paradigm of the verb 'give' with Sumshot ...
Utt, Tyler P.
core  

Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy

Molecular Oncology, EarlyView.
LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir, Elena Haro‐Martínez, Sandra Blasco‐Benito, Chiara Cannatà, José Ángel Palomeque, Anna López‐Plana, Maria Sanz‐Flores, Marc Sabartés, Cristina Fornaguera, Toni Celià‐Terrassa   +9 more
wiley   +1 more source

Discrete Unilateral Constrained Extended Kalman Filter in an Embedded System

Sensors
Since its publication in the 1960s, the Kalman Filter (KF) has been a powerful tool in optimal state estimation. However, the KF and most of its variants have mainly focused on the state estimation of smooth systems.
Leonardo Herrera, Rodrigo Méndez-Ramírez   +1 more
doaj   +1 more source

Transitions and paradigms [PDF]

Journal of Epidemiology and Community Health, 2004
“Poverty is the inability to command events that affect our lives.” At this important time of crisis, I am reminded of the work of three of my good friends: Jonas Salk, Ernest Callenbach, Tarzie Vittachi. Each has contributed something very important in trying to understand the future. Jonas Salk, involved with bacteriology, chose as a metaphor the S
openaire   +2 more sources