Results 61 to 70 of about 1,188,380 (318)

From paradigm blindness to paradigm shift? An integrative review and critical analysis of the regenerative paradigm

Amid growing concerns over sustainable development failures, scholars are exploring the ‘regenerative paradigm’ as a pathway for systemic change; yet, its paradigmatic foundations remain underexamined. Using thematic analysis, we analyse the regenerative
Becken, Susanne, Westoby, Ross, Taveras-Dalmau, Vanessa   +2 more
core   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Weakening the nuclear envelope: Lamin B receptor in melanoma metastasis

Molecular Oncology, EarlyView.
LBR‐driven nuclear fragility supports melanoma invasion. A: Melanocyte presents low LBR (Lamin B Receptor) levels, maintaining nuclear integrity and lamina‐chromatin tethering. B: During malignant progression, upregulation of LBR clusters at the INM (Inner Nuclear Membrane) during confined migration causes local lamina weakening and cholesterol ...
Francesca Lorenzini, Maria Caterina Mione   +1 more
wiley   +1 more source

Unravelling Bangalore's air quality during the second wave: Multifaceted analysis of COVID-19 lockdown impact

Natural Hazards Research
This study assesses the impact of the second wave COVID-19 lockdown (March–June 2021) on air pollution levels in Bangalore, India, using real-time data from eight CPCB monitoring stations across the city.
Iranna Gogeri, Krushna Chandra Gouda, Aruna Singanahalli ThippaReddy   +2 more
doaj   +1 more source

MiR‐513a promotes human erythroid differentiation by modulating c‐Jun

FEBS Open Bio, EarlyView.
During early human erythropoiesis, miR‐513a promoted erythroid differentiation in primary human CD34+ hematopoietic stem‐progenitor cells and human TF‐1 erythroleukemic cells by indirectly decreasing c‐Jun and phospho‐c‐Jun expression, which are associated with increased GATA1 expression.
MinJung Kim, Brittany Taylor, Shannon Bolten, Christian L. Eberly, Mahliya Abdurahman, T. Michael Creed, Acong Yang, Taylor L. Hatchet, Tristan Dyson, Shuo Gu, Curt I. Civin, Tami J. Kingsbury   +11 more
wiley   +1 more source

P016: Results of an open-label, single-center, clinical study evaluating the safety and tolerability of pentosan polysulfate sodium in mucopolysaccharidosis I subjects

Genetics in Medicine Open, 2023
Curtis Gravance, Drago Bratkovic, David Ketteridge, Michael Imperiale, Ravi Krishnan, Divya Navuru   +5 more
doaj   +1 more source

Validation of the formulation of location quotient methods using regression analysis

Journal of Economic Structures
The location quotient (LQ) method, a widely used nonsurvey method, has been improved through a series of empirical studies, resulting in variations that incorporate various factors. These variations include the simple LQ (SLQ) method, which considers the
Mizuki Uchida
doaj   +1 more source

Short- and Long-Term Effects of Undernutrition During Adolescence on Oxidative Status and Glucose Homeostasis in Male and Female Rats

Biology
Malnutrition during adolescence can cause metabolic diseases later in life. This study examined the short- and long-term effects of undernutrition during adolescence on body composition, glucose homeostasis and redox balance. Male (n = 32) and female (n =
Joskame Saint Paul, Antônio José Rocha Ribeiro, Ana Caroline Schoenberger Kipper, Mariele de Oliveira Souza, Thiara Chaves dos Santos, Karoline Paiva da Silva, Aline Milena Dantas Rodrigues, Manoela Fontenele Antunes, Isabelle Zanata Fabiane, Ana Júlia Lopes Braga Ferneda, Valéria Dornelles Gindri Sinhorin, Renata de Azevedo Melo Luvizotto, Júlio Cezar de Oliveira   +12 more
doaj   +1 more source

Improved Positive Predictive Performance of Listeria Indicator Broth: A Sensitive Environmental Screening Test to Identify Presumptively Positive Swab Samples

Microorganisms, 2019
PDX-LIB, Listeria Indicator Broth, was developed as a proprietary sensitive screening test to identify presumptively positive environmental swab samples for Listeria sp.
Alan D. Olstein, Joellen M. Feirtag
doaj   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source