Results 71 to 80 of about 3,013,242 (348)

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Unravelling Bangalore's air quality during the second wave: Multifaceted analysis of COVID-19 lockdown impact

Natural Hazards Research
This study assesses the impact of the second wave COVID-19 lockdown (March–June 2021) on air pollution levels in Bangalore, India, using real-time data from eight CPCB monitoring stations across the city.
Iranna Gogeri, Krushna Chandra Gouda, Aruna Singanahalli ThippaReddy   +2 more
doaj   +1 more source

Too Much Heart and Not Enough Heat: The Short Life and Fractured Ego of the Empathic, Heroic Public Defender [PDF]

, 2004
In this Article I will examine Professor Ogletree\u27s paradigm for motivating and sustaining public defenders ten years after he proposed it. I will discuss whether Professor Ogletree\u27s paradigm works for defenders in the predominantly high-volume ...
Smith, Abbe
core   +1 more source

Transitions and paradigms [PDF]

Journal of Epidemiology and Community Health, 2004
“Poverty is the inability to command events that affect our lives.” At this important time of crisis, I am reminded of the work of three of my good friends: Jonas Salk, Ernest Callenbach, Tarzie Vittachi. Each has contributed something very important in trying to understand the future. Jonas Salk, involved with bacteriology, chose as a metaphor the S
openaire   +3 more sources

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Holistic Learning: A workforce development paradigm [PDF]

, 2015
The development of workforce knowledge, skills and attitudes are widely acknowledged in extant literature as being pivotal levers to deliver process improvement and efficiency.
Adjaie John, Godfaurd, Ene, Gloria Unoma, Goulding, Jack Steven, Pour Rahimian Leilabadi, Farzad   +3 more
core   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Short- and Long-Term Effects of Undernutrition During Adolescence on Oxidative Status and Glucose Homeostasis in Male and Female Rats

Biology
Malnutrition during adolescence can cause metabolic diseases later in life. This study examined the short- and long-term effects of undernutrition during adolescence on body composition, glucose homeostasis and redox balance. Male (n = 32) and female (n =
Joskame Saint Paul, Antônio José Rocha Ribeiro, Ana Caroline Schoenberger Kipper, Mariele de Oliveira Souza, Thiara Chaves dos Santos, Karoline Paiva da Silva, Aline Milena Dantas Rodrigues, Manoela Fontenele Antunes, Isabelle Zanata Fabiane, Ana Júlia Lopes Braga Ferneda, Valéria Dornelles Gindri Sinhorin, Renata de Azevedo Melo Luvizotto, Júlio Cezar de Oliveira   +12 more
doaj   +1 more source

Improved Positive Predictive Performance of Listeria Indicator Broth: A Sensitive Environmental Screening Test to Identify Presumptively Positive Swab Samples

Microorganisms, 2019
PDX-LIB, Listeria Indicator Broth, was developed as a proprietary sensitive screening test to identify presumptively positive environmental swab samples for Listeria sp.
Alan D. Olstein, Joellen M. Feirtag
doaj   +1 more source

Model Extraction Warning in MLaaS Paradigm

, 2017
Cloud vendors are increasingly offering machine learning services as part of their platform and services portfolios. These services enable the deployment of machine learning models on the cloud that are offered on a pay-per-query basis to application ...
Carlini N., Papernot N., Rangwala Maimuna H, Tramèr Florian, Wang B.   +4 more
core   +1 more source