Results 81 to 90 of about 3,013,242 (348)

Blocking the voltage‐gated sodium channel hNav1.5 as a novel pH‐dependent mechanism of action for tamoxifen

FEBS Open Bio, EarlyView.
Patch‐clamp recordings revealed that tamoxifen inhibits voltage‐gated sodium channels, especially under acidic conditions, both common in metastatic cancer cells. These effects may explain certain antitumor properties of tamoxifen, highlighting a novel mechanism of action beyond its known endocrine effects.
Karl Josef Föhr, Michael Fauler, Thomas Zimmer, Bettina Jungwirth, Hubert Schrezenmeier, David Alexander Christian Messerer   +5 more
wiley   +1 more source

P016: Results of an open-label, single-center, clinical study evaluating the safety and tolerability of pentosan polysulfate sodium in mucopolysaccharidosis I subjects

Genetics in Medicine Open, 2023
Curtis Gravance, Drago Bratkovic, David Ketteridge, Michael Imperiale, Ravi Krishnan, Divya Navuru   +5 more
doaj   +1 more source

THE PARADIGM OF INFLATION [PDF]

, 2005
The standard model of cosmology is based on the hot Big Bang theory and the inflationary paradigm. Recent precise observations of the temperature and polarization anisotropies in the cosmic microwave background and the matter distribution in large scale structures like galaxies and clusters confirm the general paradigm and put severe constrains on ...
openaire   +3 more sources

Transcriptional regulation of neuropeptide receptors underlies context‐dependent adaptation in Drosophila melanogaster

FEBS Open Bio, EarlyView.
Under environmental changes, the expression level of neuropeptide (NP) and neuropeptide receptor (NPR) genes changes to confer context‐dependent adaptation to the model organism Drosophila melanogaster. Through finding more regulatory elements in the NPR genes in comparison with their ligands (NPs), we found that NPR‐biased transcriptional regulation ...
SeungHeui Ryu, Yanan Wei, Zekun Wu, Tianmu Zhang, DoHoon Lee, Hadi Najafi, Woo Jae Kim   +6 more
wiley   +1 more source

Improved clinical outcome measures of knee pain and function with concurrent resolution of subchondral Bone Marrow Edema Lesion and joint effusion in an osteoarthritic patient following Pentosan Polysulphate Sodium treatment: a case report

BMC Musculoskeletal Disorders, 2017
Background At present, there are no registered products for the treatment of subchondral Bone Marrow Edema Lesion (BML) and associated knee pain. Patients who do not respond to current anti-inflammatory therapies are left with limited treatment options ...
Matthew J. Sampson, Margie Kabbani, Ravi Krishnan, Michael Nganga, Annika Theodoulou, Jeganath Krishnan   +5 more
doaj   +1 more source

COGNITIVE LINGUISTICS AS A METHODOLOGICAL PARADIGM [PDF]

, 2002
A general direction in which cognitive linguistics is heading at the turn of the century is outlined and a revised understanding of cognitive linguistics as a methodological paradigm is suggest.
Kravchenko, Prof. A.V.
core  

A flow paradigm in heavy-ion collisions

, 2018
The success of hydrodynamics in high energy heavy-ion collisions leads to a flow paradigm, to understand the observed features of harmonic flow in terms of the medium collective expansion regarding initial state geometrical properties. In this review, we
Yan, Li
core   +1 more source

Identification of amino acids essential for angulin‐1/3 binding of the tricellular tight junction binder, angubindin‐1

FEBS Open Bio, EarlyView.
Angubindin‐1 binds angulin‐1/‐3 at tricellular tight junctions, enhancing intestinal macromolecule permeation. Alanine scanning identified six essential residues (L562, L598, E638, V640, Y643, and K644) of angubindin‐1 critical for binding to angulin‐1/‐3 and permeation‐enhancing activity, providing insights for the development of targeted noninvasive ...
Taiki Kuzu, Yumi Iwashita, Keisuke Tachibana, Itsuki Nishino, Yuki Niwa, Atsuko Uyeda, Kazuki Matsuo, Masahiro Nagahama, Masuo Kondoh   +8 more
wiley   +1 more source

Extra care housing: a paradigm shift [PDF]

, 2007
This paper sets out to investigate if and how a spatial typology for extra care housing (ECH) can be defined within the context of housing for older people in the UK.
Hanson, J., Wojgani, H.
core  

Mitochondria‐associated membranes (MAMs): molecular organization, cellular functions, and their role in health and disease

FEBS Open Bio, EarlyView.
Mitochondria‐associated membranes (MAMs) are contact sites between the endoplasmic reticulum and mitochondria that regulate calcium signaling, lipid metabolism, autophagy, and stress responses. This review outlines their molecular organization, roles in cellular homeostasis, and how dysfunction drives neurodegeneration, metabolic disease, cancer, and ...
Viet Bui, Maryline Santerre, Natalia Shcherbik, Bassel E Sawaya   +3 more
wiley   +1 more source