Results 61 to 70 of about 4,608,970 (389)
Time after time – circadian clocks through the lens of oscillator theory
FEBS Letters, EarlyView.Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo +2 more
wiley +1 more source
The need for a locally relevant paradigm shift in Medical Education
Sri Lanka Journal of Medicine, 2016 The advent of technology over the past few decades has made a tremendous impact on the management of illnesses with concepts such as personalized genomic medicine being introduced.
Veranja Liyanaparthirana
doaj +1 more source
Valuing ecosystem services: A new paradigm shift [PDF]
, 2006 The ways in which economists value natural resources has been, and continues to be, a constantly evolving process. At first, only transactions that took place in the marketplace were considered.
Kaval, Pamela
core +1 more source
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
, 2011 This paper analyses the consequences of young researchers' scientifc choice on the dynamics of sciences. We develop a simple two state mean field game model to analyze the competition between two paradigms based on Kuhn's theory of scientifc revolutions.
Besancenot, Damien, Dogguy, Habib
core +2 more sources
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Quasicrystals – A Paradigm Shift in Crystallography?
CHIMIA, 2014 The discovery of quasicrystals had important consequences for our understanding of long-range order in thermodynamic equilibrium, the definition of the term 'crystal' as well as diffraction theory.
Walter Steurer
doaj +1 more source
Cancer cell heterogeneity and plasticity: A paradigm shift in glioblastoma
Neuro-Oncology, 2021 Phenotypic plasticity has emerged as a major contributor to intra-tumoral heterogeneity and treatment resistance in cancer. Increasing evidence shows that glioblastoma (GBM) cells display prominent intrinsic plasticity and reversibly adapt to dynamic ...
Y. Yabo, S. Niclou, A. Gołȩbiewska
semanticscholar +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Shifting Sugars and Shifting Paradigms
PLOS Biology, 2015 No organism lives in a constant environment. Based on classical studies in molecular biology, many have viewed microbes as following strict rules for shifting their metabolic activities when prevailing conditions change. For example, students learn that the bacterium Escherichia coli makes proteins for digesting lactose only when lactose is available ...
openaire +4 more sources