Results 51 to 60 of about 595 (262)
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
Molecular Oncology, EarlyView.Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant +11 more
wiley +1 more source
Paradigmes d’alternatives syntagmatiques : la manifestation est une compétition
Signata, 2017 In a structural point of view, paradigms are in principle and generally classifications which are reserved to the language system, to its immanent structure.
Jacques Fontanille
doaj +1 more source
Epistemic courage and health political science. [PDF]
Can J Public Health, 2023 de Leeuw E.
europepmc +1 more source
Molecular Oncology, EarlyView.The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant +7 more
wiley +1 more source
DU MAUVAIS USAGE DE LA TRADITION RECONSTITUÉE : LA MÉDIATION EXTRAJUDICIAIRE EN CHINE
The Windsor Yearbook of Access to Justice, 2012 L’étude porte sur le renouveau de la médiation extrajudiciaire en Chine abordé sous l’angle de l’accès à la justice. Ce renouveau est situé dans son contexte politique, notamment dans l’appel aux paradigmes locaux lui servant de toile de fond.
Hélène Piquet
doaj +1 more source
ADP‐ribosylation: An emerging regulator of the epigenome
Molecular Oncology, EarlyView.ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho +2 more
wiley +1 more source
La procréation assistée : conflit de paradigmes
Droit et Cultures, 2006 The Italian law regulating access to techniques of medically assisted procreation was adopted in 2004 after long debate. Its main inspiration is from the Catholic. But this law contains numerous « bridges » making it possible to circumvent the most rigid
Carlo Flamigni
doaj
Teaching poverty and health: importing transformative learning into the structures and paradigms of medical education. [PDF]
Can Med Educ J, 2022 Cartmill C +7 more
europepmc +1 more source
YIPFα1A expression is regulated by multilayered molecular mechanisms
FEBS Open Bio, EarlyView.YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji +2 more
wiley +1 more source