Results 41 to 50 of about 17,142 (229)
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Entre dois paradigmas: combate à seca e convivência com o semi-árido
Sociedade e Estado, 2003 Grande parte dos diagnósticos e proposições sobre o semi-árido brasileiro tem como referência imagens historicamente construídas sobre um espaço-problema, terra das secas e da miséria.
Roberto Marinho Alves da Silva
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Les paradigmes de l'État (3) - Les paradigmes contemporains : l' État-Providence
, 1995 Miaille Michel. Les paradigmes de l'État (3) - Les paradigmes contemporains : l' État-Providence. In: Sciences de la société, n°35, 1995. Territoire, société et communication. pp.
Miaille, Michel
core +1 more source
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
La representació occidental de la Xina moderna: orientalisme, culturalisme i crítica historiogràfica
Digithum, 2008 La percepció que des d'Occident s'ha tingut de la Xina com a ens històric ha evolucionat al llarg dels segles. La Xina va passar de ser un país de prodigis i meravelles en el món medieval i una cultura refinada i erudita al començament de la modernitat ...
David Martínez-Robles
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Les paradigmes de l 'État 2. Les paradigmes contemporains : l'État de droit
, 1994 Miaille Michel. Les paradigmes de l 'État 2. Les paradigmes contemporains : l'État de droit. In: Sciences de la société, n°33, 1994. Les organisations au risque de l'information. pp.
Miaille, Michel
core +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Introduction. Les paradigmes de la justice [PDF]
Meta: Research in Hermeneutics, Phenomenology and Practical Philosophy, 2009 Theories of justice are marred by a permanent state of conflict because they express prejudices whose source lies in the lifeworld. One may regard these theories as interpretations of the concept of justice. Assuming a strong meaning of “theory,” one can
Cornelui Bîlbă
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