Results 31 to 40 of about 1,063,823 (303)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Test Of Capital Asset Pricing Model On Stocks At Karachi Stock Exchange [PDF]

open access: yesParadigms, 2010
This paper attempts to empirically test the single-factor CAPM developed by Sharpe (1964), Lintner (1965) and Jan Mossin (1966) and others, which proposes that the expected returns of capital assets are dependent on their risk relative to the entire ...
Arbab Khalid Cheema
doaj  

World on Data Perspective

open access: yesWorld, 2022
It is not simple to consider the world from only one side, but analyzing all sides can cloud comprehension without reaching deep insight found at the core.
Mahyuddin K. M. Nasution
doaj   +1 more source

Modes and models in disorders of consciousness science [PDF]

open access: yes, 2012
The clinical assessment of non-communicative brain damaged patients is extremely difficult and there is a need for paraclinical diagnostic markers of the level of consciousness.
Boly, Mélanie, Seth, Anil K
core   +1 more source

Probabilistic Modeling Paradigms for Audio Source Separation [PDF]

open access: yes, 2010
This is the author's final version of the article, first published as E. Vincent, M. G. Jafari, S. A. Abdallah, M. D. Plumbley, M. E. Davies. Probabilistic Modeling Paradigms for Audio Source Separation. In W.
A. P.Dempster   +10 more
core   +5 more sources

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

PERCEIVED SERVICE QUALITY IN CONTEXT OF RURAL AND URBAN BANKS IN PAKISTAN [PDF]

open access: yesParadigms, 2016
Perceived service quality is very important concept in banking sector. It is therefore necessary to acknowledge the perception of customers from different areas-as they are becoming more critical and demanding.
MUHAMMAD FAROOQ SHABBIR   +4 more
doaj  

Transitions and paradigms [PDF]

open access: yesJournal of Epidemiology and Community Health, 2004
“Poverty is the inability to command events that affect our lives.” At this important time of crisis, I am reminded of the work of three of my good friends: Jonas Salk, Ernest Callenbach, Tarzie Vittachi. Each has contributed something very important in trying to understand the future. Jonas Salk, involved with bacteriology, chose as a metaphor the S
openaire   +2 more sources

Computational Models of Tutor Feedback in Language Acquisition

open access: yes, 2017
This paper investigates the role of tutor feedback in language learning using computational models. We compare two dominant paradigms in language learning: interactive learning and cross-situational learning - which differ primarily in the role of social
Nevens, Jens, Spranger, Michael
core   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

open access: yesFEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas   +3 more
wiley   +1 more source

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