Results 41 to 50 of about 113,963 (269)
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Diabetes, Metabolic Syndrome and Obesity, 2020 Yu-Hsuan Li,1,2 Wayne Huey-Herng Sheu,1,3,4 I-Te Lee1,3,5,6 1Division of Endocrinology and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung 40705, Taiwan; 2Graduate Institute of Data Science, Taipei Medical ...
Li YH, Sheu WHH, Lee IT
doaj
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
Metáforas y paradojas de los miedos en los sujetos docentes
Revista Latinoamericana en Ciencias Sociales, Niñez y Juventud, 2014 We deal with the fears felt by Colombian University professors using as point of departure some life testimonies, considering that this is a country that has been characterized by a lot of violence since colonial times, going through the independence ...
Miguel Alberto González-González
doaj +1 more source
Politico-Legal Review of the Revised-Bill of the Corruption Eradication Commission and Omnibus Law
Jurnal Media Hukum, 2021 The paper aims to prove that political compromise may create legal antagonisms, paradoxes and strengthen the influence of elite-oligarchy. The paper is based on the theory that the concept of consensus in the context of the political system is closely ...
JM Muslimin, Novita Akria Putri
doaj +1 more source
Molecular Oncology, EarlyView.Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park +6 more
wiley +1 more source
Fuzzy Epistemology From View Point of Mystical Theology
Kanz Philosophia: A Journal for Islamic Philosophy and Mysticism, 2012 Abstrak : Isu imanensi dan transendensi sangat penting dalam pemikiran keagamaan. Salah satu alasan mengapa masalah ini tidak pernah terselesaikan adalah bahwa ia memiliki banyak makna dan muncul dalam konteks yang berbeda.
Hadi Vakili
doaj +1 more source