Results 61 to 70 of about 1,405,451 (393)
Managing the Tradition and Innovation Paradox in Family Firms: A Family Imprinting Perspective
Entrepreneurship: Theory & Practice, 2020 Long-established family firms are endowed with a bundle of beliefs and practices that constitute their tradition. However, to remain competitive, they need to renew their products and production processes.
Irmak Erdogan +2 more
semanticscholar +1 more source
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
To Overcome Ethical Dilemmas in an Organization: Paradox and Ethics of Freedom Can Help [PDF]
Business Ethics and LeadershipA theoretical model for managers responding to a morally challenging situation is developed in the article. This model explores and examines how managers deal with paradoxes created by ethical dilemmas.
Benoît Cherré, Nathalie Lemieux
doaj +1 more source
RIPK4 function interferes with melanoma cell adhesion and metastasis
Molecular Oncology, EarlyView.RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski +9 more
wiley +1 more source
Pervasive Technologies and the Paradoxes of Multimodal Digital Communication
Lea, 2014 Contemporary societies are greatly challenged by paradoxes in all facets of life. Digital communication encodes and produces meaning by making use of these contradictory relations. In this contribution, three digital paradoxes will be presented.
Sandra Petroni
doaj +1 more source
M@n@gement, 2022 Hospitals are looking to strengthen their safety culture by learning internally from medical errors that occur to prevent them from happening again. This implies creating an atmosphere of psychological safety that encourages errors to be reported.
Julien Cusin, Anne Goujon-Belghit
doaj +1 more source
The ‘Principles’ Paradox [PDF]
, 2009 This essay, prepared for a University of Cambridge conference on ‘Principles Versus Rules in Financial Regulation’, posits a new issue in that debate. Although principles-based regulation is thought to more closely achieve normative goals than rules, the
Schwarcz, Steven L.
core +2 more sources
European Journal of Psychotraumatology, 2021 Decades of research have consistently shown that the most common outcome following potential trauma is a stable trajectory of healthy functioning, or resilience.
G. Bonanno
semanticscholar +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Civil Disobedience, Costly Signals, and Leveraging Injustice
Ergo, An Open Access Journal of Philosophy, 2021 Civil disobedience, despite its illegal nature, can sometimes be justified vis-à-vis the duty to obey the law, and, arguably, is thereby not liable to legal punishment.
Ten-Herng Lai
doaj +2 more sources