Results 71 to 80 of about 1,405,451 (393)
Journal of the American College of Cardiology, 2014 Paradoxical embolism is an important clinical entity among patients with venous thromboembolism in the presence of intracardiac or pulmonary shunts. The clinical presentation is diverse and potentially life-threatening. Although the serious nature and complications of paradoxical embolism are recognized, the disease entity is still rarely considered ...
Windecker, Stephan +2 more
openaire +2 more sources
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
Outlaw Lovers and Aporetic Politics: Derrida’s The Politics of Friendship and Sherman Alexie’s ‘South by Southwest’ [PDF]
Limina: A Journal of Historical and Cultural Studies, 2014 This article provides a comparative reading of Jacques Derrida’s The Politics of Friendship with Sherman Alexie’s short story ‘South by Southwest’. In these texts, ‘friendship’ or love is impossible to achieve by seeking conformance to pre-existing ...
Mara Steele
doaj
Epilog. Living with the perplexities of our being-in-the-world with others: the paradox of Bildung
Studia z Teorii Wychowania, 2023 One of the most powerful challenges of being in the world with Others is learning when to be aff ected by power beyond our wanting and doing. Th e hermeneutic experience of art highlights the power of letting things show themselves to us and provoke ...
Andrzej Wierciński
doaj +1 more source
Insights into a long life without cancer: The case of the bowhead whale
Molecular Oncology, EarlyView.Long‐lived, large‐bodied organisms have evolved powerful anticancer mechanisms that preserve cellular and tissue integrity across extended lifespans. A recent study by Firsanov et al. shows that greater genome stability is a key factor underlying the remarkable longevity and cancer resistance of one such species, the bowhead whale.
Inés Paniagua, Johanna A. Joyce
wiley +1 more source
Checkpoint blockade and the stem‐like T cell trade‐off
Molecular Oncology, EarlyView.Stem‐like T cells are key to the success of programmed cell death protein 1 (PD1) blockade, as they sustain long‐term anti‐tumor response by continuously generating effector CD8+ T cells. However, how these cells are maintained in cancer is not fully understood. Hor et al.
Julie M. Mazet, Johanna A. Joyce
wiley +1 more source
Sparks of reality: on the temporalities of the photographic image
Aisthesis, 2018 Within the context of the contemporary heterogeneity of photographic practices, the present text describes some of the possibilities of understanding the temporality of photographs, giving an account of some important theoretical references (Benjamin ...
Nélio Conceição
doaj
The surprise exam paradox: a note on formulating it and a solution to it [PDF]
, 2019 Some formulations of the surprise paradox involve a pair of unnecessary and controversial assumptions.
Edward, Terence Rajivan
core
The role of lipid metabolism in neuronal senescence
FEBS Open Bio, EarlyView.Disrupted lipid metabolism, through alterations in lipid species or lipid droplet accumulation, can drive neuronal senescence. However, lipid dyshomeostasis can also occur alongside neuronal senescence, further amplifying tissue damage. Delineating how lipid‐induced senescence emerges in neurons and glial cells, and how it contributes to ageing and ...
Dikaia Tsagkari +2 more
wiley +1 more source
, 2002 Kraut et al. (1998) reported negative effects of using the Internet on social involvement and psychological well-being among new Internet users in 1995–96. We called the effects a “paradox” because participants used the Internet heavily for communication,
R. Kraut +5 more
semanticscholar +1 more source