Results 71 to 80 of about 91,828 (299)

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

open access: yesMolecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute   +4 more
wiley   +1 more source

Analysis of magnetic treatment of production fluid with high content of asphalt-resin-paraffin deposits [PDF]

open access: yes, 2017
Purpose. Justification of magnetic field application in order to prevent formation of asphalt-resin-paraffin deposits (ARPD) in oil and gas equipment, and consider some current views on the state of ARPD problem in oilfield equipment and possible methods
Kharchenko, M   +3 more
core   +2 more sources

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Effect of nanomaterial addition on the thermophysical properties of Iraqi paraffin wax

open access: yesCase Studies in Thermal Engineering, 2019
The storage and transfer speed of heat have become important topics in modern applications, particularly photovoltaic thermal (PV/T) applications. One of the latest developments in this field is the use of phase-change materials because of their ability ...
Ahmed H. Ali   +4 more
doaj   +1 more source

Fabrication of Microfluidic Chips Based on an EHD-Assisted Direct Printing Method

open access: yesSensors, 2020
Microfluidic chips have been widely used in many areas such as biology, environmental monitoring, and micromixing. With the increasing popularity and complexity of microfluidic systems, rapid and convenient approaches for fabricating microfluidic chips ...
Xiang Chi   +6 more
doaj   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

open access: yesMolecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova   +14 more
wiley   +1 more source

Complex Geometry Cellulose Hydrogels Using a Direct Casting Method

open access: yesBioengineering, 2020
To facilitate functional hydrogel part production using the indirect wax mould method, it is necessary to understand the relationships between materials, process and mould removal. This research investigated the thermophysical properties, wettability and
Hossein Najaf Zadeh   +4 more
doaj   +1 more source

Phase change composite bimorphs [PDF]

open access: yes, 2018
A bilayer composite thin-film beam structure is described. The structure incorporates a bulk phase change material as small inclusions in one layer of a bimorph.
Blonder, Greg
core  

Generalized bioinspired approach to a daytime radiative cooling "skin"

open access: yes, 2020
Energy-saving cooling materials with strong operability are desirable towards sustainable thermal management. Inspired by the cooperative thermo-optical effect in fur of polar bear, we develop a flexible and reusable cooling skin via laminating a ...
Guo, Jing   +9 more
core   +1 more source

Analysis of thermal-probe measurements using an iterative method to give sample conductivity and diffusivity data [PDF]

open access: yes, 2003
The application of Microsoft Excel Solver routines to analyze data from a thermal probe placed in a number of samples is described. The successful application of the Solver routine to the thermal probe temperature time data requires the selection of an ...
Goodhew, SMR, Griffiths, R
core   +1 more source

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