Results 1 to 10 of about 65,500 (223)

Protective antibodies against human parainfluenza virus type 3 infection [PDF]

mAbs, 2021
Human parainfluenza virus type III (HPIV3) is a common respiratory pathogen that afflicts children and can be fatal in vulnerable populations, including the immunocompromised. There are currently no effective vaccines or therapeutics available, resulting
Jim Boonyaratanakornkit, Suruchi Singh, Connor Weidle, Justas Rodarte, Ramasamy Bakthavatsalam, Jonathan Perkins, Guillaume B.E. Stewart-Jones, Peter D. Kwong, Andrew T. McGuire, Marie Pancera, Justin J. Taylor   +10 more
doaj   +3 more sources

T-Cell Therapeutics Targeting Human Parainfluenza Virus 3 Are Broadly Epitope Specific and Are Cross Reactive With Human Parainfluenza Virus 1 [PDF]

Frontiers in Immunology, 2020
Human Parainfluenza Virus-3 (HPIV3) causes severe respiratory illness in immunocompromised patients and lacks approved anti-viral therapies. A phase I study of adoptively transferred virus-specific T-cells (VSTs) targeting HPIV3 following bone marrow ...
Katherine M. Harris, Katherine M. Harris, Sarah E. Horn, Melanie L. Grant, Haili Lang, Gelina Sani, Mariah A. Jensen-Wachspress, Vaishnavi V. Kankate, Anushree Datar, Christopher A. Lazarski, Catherine M. Bollard, Catherine M. Bollard, Catherine M. Bollard, Michael D. Keller, Michael D. Keller, Michael D. Keller   +15 more
doaj   +3 more sources

Respiratory Viral Co-Infections in SARS-CoV-2 Positive Patients in Burkina Faso: A Cross-Sectional Study. [PDF]

Health Sci Rep
ABSTRACT Background The burden of viral co‐infections among COVID‐19 patients is underexplored in low‐resource settings such as Burkina Faso. This study aimed to determine the prevalence and associated factors of respiratory viral co‐infections among laboratory‐confirmed COVID‐19 patients. Methods A cross‐sectional study was conducted from January 1 to
Kaboré BWO, Gouba N, Ilboudo AK, Cissé A, Lingani M, Sawadogo C, Ouédraogo EW, Ouoba JB, Savadogo M, Tarnagda Z.   +9 more
europepmc   +2 more sources

Modeling Infection and Tropism of Human Parainfluenza Virus Type 3 in Ferrets

mBio, 2022
Human parainfluenza virus type 3 (HPIV-3) is a significant cause of lower respiratory tract infections, with the most severe disease in young infants, immunocompromised individuals, and the elderly.
Laurine C. Rijsbergen, Katharina S. Schmitz, Lineke Begeman, Jennifer Drew-Bear, Lennert Gommers, Mart M. Lamers, Alexander L. Greninger, Bart L. Haagmans, Matteo Porotto, Rik L. de Swart, Anne Moscona, Rory D. de Vries   +11 more
doaj   +5 more sources

Leveraging human precision cut lung slices for the study of human parainfluenza virus 3 infection [PDF]

Respiratory Research
Human parainfluenza virus 3 is a highly abundant RNA virus that primarily affects young children, the elderly, and immunocompromised individuals, leading to severe lower respiratory infections and pneumonia.
Olga Danov, Philippe Vollmer Barbosa, Helena Obernolte, Maximilian Fuchs, Patrice Guillon, Larissa Dirr, Ibrahim El-Deeb, Meik Kunz, Leonie Hose, Gaël Martin, Fabian Röpken, Anna Zimmer, Lavinia Neubert, Danny Jonigk, Hans-Gerd Fieguth, Franziska Dahlmann, Sabine Wronski, Mark von Itzstein, Thomas Tschernig, Armin Braun, Katherina Sewald   +20 more
doaj   +2 more sources

Long-Term Trends in Human Parainfluenza Virus Types 1, 2, and 3 Infection in Korea (2007–2024) [PDF]

Pathogens
This study investigated the long-term trends in human parainfluenza virus (HPIV) types 1, 2, and 3 in Korea by year, age group, and season. A total of 23,284 nasopharyngeal swabs collected from patients with respiratory symptoms at a tertiary hospital in
Yu Jeong Kim, Jeong Su Han, Jae-Sik Jeon, Sung Hun Jang, Qianwen Wang, Jae Kyung Kim   +5 more
doaj   +2 more sources

Human parainfluenza virus surveillance in pediatric patients with lower respiratory tract infections: a special view of parainfluenza type 4

Jornal de Pediatria (Versão em Português), 2018
Objective: Characterize the role of human parainfluenza virus and its clinical features in Brazilian children under 2 years of age presenting with acute lower respiratory tract infections.
Luciano M. Thomazelli, Danielle B.L. de Oliveira, Giuliana S. Durigon, Brett Whitaker, Shifaq Kamili, Eitan N. Berezin, Edison L. Durigon   +6 more
doaj   +3 more sources

Multicenter Evaluation of the QIAstat-Dx Respiratory Panel for the Detection of Viruses and Bacteria in Nasopharyngeal Swab Specimens [PDF]

, 2020
The QIAstat-Dx Respiratory Panel (QIAstat-Dx RP) is a multiplex in vitro diagnostic test for the qualitative detection of 20 pathogens directly from nasopharyngeal swab (NPS) specimens. The assay is performed using a simple sample-to-answer platform with
Granato, Paul, Hannet, Irene, Hansen, Glen, Leber, Amy L., Lisby, Jan Gorm, Pareja, Josep, Relich, Ryan F., Schneider, Uffe Vest, Young, Stephen   +8 more
core   +1 more source

The Clinical Performance of the BioCode Respiratory Pathogen Panel for the Detection of Viruses and Bacteria from Nasopharyngeal Swabs

Microbiology Spectrum, 2023
Early detection of microbial pathogens causing respiratory tract infection plays a crucial role in clinical management. The BioCode Respiratory Pathogen Panel (BioCode RPP) utilizes reverse transcriptase PCR (RT-PCR) in combination with barcoded magnetic
Xin Zhang, Colleen Knoth, Anh Pham, Amorce Lima, Rosario Dominguez, Irvin Ibarra-Flores, Juan C. Lopez, Dominic Uy, Suzane Silbert, Anami Patel, Michael Aye, Yi-Wei Tang, Jennifer Dien Bard   +12 more
doaj   +1 more source

Innate Intracellular Antiviral Responses Restrict the Amplification of Defective Virus Genomes of Parainfluenza Virus 5. [PDF]

, 2020
During the replication of parainfluenza virus 5 (PIV5), copyback defective virus genomes (DVGs) are erroneously produced and are packaged into "infectious" virus particles.
Goodbourn, S, Hughes, DJ, Randall, RE, Short, JAL, Vasou, A, Wignall-Fleming, EB, Young, D   +6 more
core   +3 more sources