Results 181 to 190 of about 65,500 (223)

The Catalytic Mechanism of Human Parainfluenza Virus Type 3 Haemagglutinin‐Neuraminidase Revealed

Angewandte Chemie, 2015
AbstractHuman parainfluenza virus type 3 (hPIV‐3) is one of the leading causes for lower respiratory tract disease in children, with neither an approved antiviral drug nor vaccine available to date. Understanding the catalytic mechanism of human parainfluenza virus haemagglutinin‐neuraminidase (HN) protein is key to the design of specific inhibitors ...
Dirr, Larissa, El-Deeb, Ibrahim Mustafa, Guillon, Patrice, Carroux, Cindy, M. G. Chavas, Leonard, von Itzstein, Mark   +5 more
openaire   +6 more sources

Liver Enzyme Elevation Related to Human Parainfluenza Virus Type 3 Infection

Pediatric Infectious Disease Journal, 2022
The human parainfluenza viruses are common causes of upper and lower respiratory tract infection; however, nonrespiratory infections with human parainfluenza viruses are rare, and there are no reports of pediatric cases of liver enzyme elevation. We present 2 pediatric patients who developed liver enzyme elevation related to human parainfluenza virus ...
Yoshimasa Kudo, Tomohiro Wakabayashi, Shuichi Miyamoto, Yuta Sasaoka, Yoshiyuki Sakai, Takeshi Tsugawa   +5 more
openaire   +2 more sources

Proteins associated with human parainfluenza virus type 3

Journal of Virology, 1985
The polypeptides associated with human parainfluenza virus type 3 were identified. Five proteins were present in detergent- and salt-resistant viral cores. Of these, three proteins designated NP0, NP1, and NP2 of 68,000, 58,000, and 52,000 daltons, respectively, were stably associated with 50S RNA in CsCl gradient-purified nucleocapsids. The amounts of
R C, Jambou, N, Elango, S, Venkatesan
openaire   +2 more sources

Defective interfering particles of human parainfluenza virus 3

Virology, 1987
A cyclic pattern of virus production was observed when human parainfluenza virus 3 (HPIV3) was serially passaged nine times in LLC-MK2 cells. Viruses produced from serial passages 8 and 9 interfered with the replication of standard HPIV3. Three subgenomic RNA species (DI-1, DI-2, and DI-3) and virus genomic RNA were detected in the progeny virions ...
D G, Murphy, K, Dimock, C Y, Kang
openaire   +2 more sources

Inoculation of Human Volunteers with Parainfluenza Virus Type 3

JAMA, 1961
In an attempt to see whether parainfluenza virus type 3 would produce illness in adults, 28 adult volunteer subjects were inoculated with either the virus or a sterile salt solution. Twelve of the 17 volunteers inoculated with the virus, and none of the 11 who received the placebo inoculum, developed laboratory evidence of infection with parainfluenza ...
A Z, KAPIKIAN, R M, CHANOCK, T E, REICHELDERFER, T G, WARD, R J, HUEBNER, J A, BELL   +5 more
openaire   +2 more sources

Intracellular synthesis of human parainfluenza type 3 virus-specified polypeptides

Journal of Virology, 1985
The intracellular synthesis of human parainfluenza type 3 virus-specified polypeptides was examined by polyacrylamide gel electrophoresis of [35S]methionine-labeled cell extracts under reducing conditions. All of the virion structural proteins were detected in cell extracts, including: L, 180,000 molecular weight (180K); P, 83K; HN, 69K; NP, 66K; F0 ...
S L, Wechsler, D M, Lambert, M S, Galinski, M W, Pons   +3 more
openaire   +2 more sources

Evolution of the fusion protein gene of human parainfluenza virus 3

Virus Research, 1992
The nucleotide sequences of the fusion (F) gene of 15 clinical strains of human parainfluenza virus 3 (HPIV3) isolated between 1959 and 1987 were compared with the F gene sequence of the prototype strain, Wash/47885/57. Nucleotide sequence diversity was greatest in the noncoding regions of the F gene; however, regions believed to function as ...
K, Prinoski, M J, Côté, C Y, Kang, K, Dimock   +3 more
openaire   +2 more sources

Characterization of human parainfluenza virus-3 circulating in Israel, 2012-2015

Journal of Clinical Virology, 2018
Human parainfluenza virus 3 (hPIV-3) causes respiratory tract infection.The objective of this study was to describe the epidemiology of hPIV-3 infection among hospitalized patients and characterize the circulating strains.A cross-sectional study was conducted using respiratory samples of 15,946 hospitalized patients with respiratory symptoms in 2012 ...
Irina Jornist, Khitam Muhsen, Daniela Ram, Yaniv Lustig, Virginia Levy, Sara Orzitser, Roberto Azar, Merav Weil, Viki Indenbaum, Danit Sofer, Ella Mendelson, Michal Mandelboim, Musa Hindiyeh   +12 more
openaire   +2 more sources

Human infection by a bovine strain of parainfluenza virus type 3

Journal of Medical Virology, 1980
AbstractEtiological relationship between a bovine strain of parainfluenza virus type 3 and pneumonia in a child is suggested. Haemagglutination inhibition tests have clearly demonstrated that specific antibodies against the bovine virus were present in the patient's serum. The significance of this finding in relation to human infection is discussed.
Z, Ben-Ishai, V, Naftali, A, Avram, S, Yatziv   +3 more
openaire   +2 more sources