Results 191 to 200 of about 65,500 (223)

Human Parainfluenza Virus 3 Neuraminidase Activity Contributes to Dendritic Cell Maturation

Viral Immunology, 2005
Mechanisms of dendritic cells (DCs) immunomodulation by parainfluenza viruses have not been characterized. We analyzed whether the human parainfluenza 3 (HPF3) virus hemagglutinin-neuraminidase glycoprotein (HN) might influence DC maturation. HN possesses a receptor binding function and a neuraminidase or desialidating activity.
Horga, MA, Macip, S, Tuyama, AC, Tan, MC, Gusella, GL   +4 more
openaire   +3 more sources

Cloning and gene assignment of mRNAs of human parainfluenza virus 3

Virology, 1985
Cytoplasmic poly(A)-containing RNA from parainfluenza virus 3-infected cells was used as template to construct a cDNA library that was cloned into the EcoRV site of the plasmid pMG5. The resulting clones were screened with [32P]-labeled cDNA probes made from infected and mock-infected cell mRNAs.
A, Sánchez, A K, Banerjee
openaire   +2 more sources

The human parainfluenza virus type 3 (HPIV 3) C protein inhibits viral transcription

Virus Research, 2004
The C protein of human parainfluenza virus type 3 (HPIV 3), like other paramyxovirus C proteins, is synthesized from an alternate open reading frame (ORF) encoded within the phosphoprotein (P) mRNA, in addition, to two other proteins, namely D and V, which arise from the same mRNA by a process of transcriptional editing.
Achut G, Malur, Michael A, Hoffman, Amiya K, Banerjee   +2 more
openaire   +2 more sources

ISGylation during Human Parainfluenza Virus Type 3 Infection

The Journal of Immunology
Abstract Human parainfluenza virus type 3 (HPIV3) causes lower respiratory illnesses such as pneumonia or bronchiolitis in infants, young children, and the immunocompromised. HPIV3 associated airway inflammatory diseases manifest as a result of host mediated exaggerated inflammatory response, though limited knowledge exists regarding ...
Lindsay Miller, Liyon Mehari, Michael Hoffman, Santanu Bose   +3 more
openaire   +1 more source

Regulation of human parainfluenza virus type 3 transcription.

2009
To elucidate the roles of the junctional elements in HPIV3 transcription, cDNAs were constructed containing CAT and luciferase reporter genes flanked by sequences representing the HPIV3 termini necessary for transcription, replication and packaging. Mutations to the gene end sequence abolished expression of the upstream and downstream genes.
openaire   +2 more sources

Lentivirus vector pseudotyped with human parainfluenza virus type 3 glycoproteins

Proceedings of the Second Joint 24th Annual Conference and the Annual Fall Meeting of the Biomedical Engineering Society] [Engineering in Medicine and Biology, 2003
Lentiviral vectors pseudotyped with the envelope glycoproteins of amphotropic murine leukemia virus and the G protein of vesicular stomatitis virus have been previously developed for use in human gene therapy trials. We report here the generation of infectious replication-defective HIV-1 particles pseudotyped with hemagglutinin-neuraminidase (HN) and ...
B. Grzybowski, S. Tong, R.W. Compans, J.M. Le Doux   +3 more
openaire   +1 more source

Functional chimeric HN glycoproteins derived from Newcastle disease virus and human parainfluenza virus-3

1997
Newcastle disease virus (NDV) is primarily a respiratory tract pathogen of birds, particularly chickens, but it occasionally produces infection in man. Human parainfluenza virus type 3 (hPIV3) is a common respiratory pathogen, particularly in young children. These two viruses gain entry to host cells via direct fusion between the viral envelope and the
R, Deng, A M, Mirza, P J, Mahon, R M, Iorio   +3 more
openaire   +2 more sources

Sulfatide negatively regulates the fusion process of human parainfluenza virus type 3

Journal of Biochemistry, 2012
Sulfatide (HSO(3)-3-galactosylceramide), which enriched in lipid rafts of plasma membranes in various epithelial cell lines, is a critical component of host cells for effective production of influenza A virus. However, the function of sulfatide in other virus infections targeting epithelial cells remains unknown.
Tadanobu, Takahashi, Kazuhiko, Ito, Keijo, Fukushima, Masahiro, Takaguchi, Takuya, Hayakawa, Yasuo, Suzuki, Takashi, Suzuki   +6 more
openaire   +2 more sources

Antigenic and functional organization of human parainfluenza virus type 3 fusion glycoprotein

Journal of Virology, 1989
Twenty-six monoclonal antibodies (MAbs) (14 neutralizing and 12 nonneutralizing) were used to examine the antigenic structure, biological properties, and natural variation of the fusion (F) glycoprotein of human type 3 parainfluenza virus (PIV3). Analysis of laboratory-selected antigenic variants and of PIV3 clinical isolates indicated that the panel ...
K, van Wyke Coelingh, E L, Tierney
openaire   +2 more sources

Attenuation of Bovine Parainfluenza Virus Type 3 in Nonhuman Primates and Its Ability to Confer Immunity to Human Parainfluenza Virus Type 3 Challenge

Journal of Infectious Diseases, 1988
Bovine parainfluenza virus type 3 (PIV-3) was evaluated as a candidate live-virus vaccine to protect against infection with human PIV-3. The level of replication of bovine and human PIV-3 and the efficacy of immunization with bovine PIV-3 in protecting against subsequent challenge with human PIV-3 was evaluated in nonhuman primates.
K L, van Wyke Coelingh, C C, Winter, E L, Tierney, W T, London, B R, Murphy   +4 more
openaire   +2 more sources