Results 41 to 50 of about 2,893,836 (306)
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
Hybrid CPU-GPU Community Detection in Weighted Networks
IEEE Access, 2020 Recently, a new trend has emerged in the field of parallel and high performance computing, the hybrid implementation using CPU-GPU modules. In such implementations, the computational load is shared between the CPU and GPU, in order to improve the ...
Stavros Souravlas +2 more
doaj +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Dynamic Skyline Computation with LSD Trees
Analytics, 2023 Given a set of high-dimensional feature vectors S⊂Rn, the skyline or Pareto problem is to report the subset of vectors in S that are not dominated by any vector of S.
Dominik Köppl
doaj +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Driving Cars by Means of Genetic Algorithms [PDF]
, 2008 Proceedings of: 10th International Conference on Parallel Problem Solving From Nature, PPSN 2008. Dortmund, Germany, September 13-17, 2008The techniques and the technologies supporting Automatic Vehicle Guidance are an important issue.
Sáez, Yago +6 more
core +1 more source
Ergonomic Chair Design by Fusing Qualitative and Quantitative Criteria using Interactive Genetic Algorithms [PDF]
, 2008 This paper emphasizes the necessity of formally bringing qualitative and quantitative criteria of ergonomic design together, and provides a novel complementary design framework with this aim. Within this framework, different design criteria are viewed
Takagi, Hideyuki +2 more
core +2 more sources
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Scheduling parallel data retrievals for non-consecutive broadcast in MIMO wireless networks
, 2012 Wireless data broadcast is usually used to disseminate the public information to considerable clients in wireless environment. Based on the development of mobile device, some mobile devices can simultaneously use multiple antennae to process some ...
Hong Shen +5 more
core +1 more source
Journal of Algorithms & Computational Technology, 2010 The numerical simulations for solving the transport equations lead to the large computation and need to implement parallel calculation. On the unstructured grids, the communicating delays, sorting algorithms and inserting algorithms limit the performance
Liu Jie +6 more
doaj +1 more source