Results 51 to 60 of about 255,237 (315)
Ergonomic Chair Design by Fusing Qualitative and Quantitative Criteria using Interactive Genetic Algorithms [PDF]
, 2008 This paper emphasizes the necessity of formally bringing qualitative and quantitative criteria of ergonomic design together, and provides a novel complementary design framework with this aim. Within this framework, different design criteria are viewed
Takagi, Hideyuki +2 more
core +1 more source
Structural parallel algorithmics [PDF]
, 1991 The first half of the paper is a general introduction which emphasizes the central role that the PRAM model of parallel computation plays in algorithmic studies for parallel computers.
openaire +1 more source
Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis
FEBS Letters, EarlyView.Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee +7 more
wiley +1 more source
Parallel Algorithms for Tensor Completion in the CP Format [PDF]
, 2015 Low-rank tensor completion addresses the task of filling in missing entries in multi-dimensional data. It has proven its versatility in numerous applications, including context-aware rec-ommender systems and multivariate function learning.
Kressner, Daniel +6 more
core +1 more source
Hybrid CPU-GPU Community Detection in Weighted Networks
IEEE Access, 2020 Recently, a new trend has emerged in the field of parallel and high performance computing, the hybrid implementation using CPU-GPU modules. In such implementations, the computational load is shared between the CPU and GPU, in order to improve the ...
Stavros Souravlas +2 more
doaj +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Journal of Algorithms & Computational Technology, 2010 The numerical simulations for solving the transport equations lead to the large computation and need to implement parallel calculation. On the unstructured grids, the communicating delays, sorting algorithms and inserting algorithms limit the performance
Liu Jie +6 more
doaj +1 more source
Dynamic Skyline Computation with LSD Trees
Analytics, 2023 Given a set of high-dimensional feature vectors S⊂Rn, the skyline or Pareto problem is to report the subset of vectors in S that are not dominated by any vector of S.
Dominik Köppl
doaj +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source