Results 61 to 70 of about 5,220,247 (383)

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

FEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan, Lu Qi, Pierre Zalloua   +2 more
wiley   +1 more source

Parallel Computation of Entries of ${A}^{-1}$ [PDF]

SIAM Journal on Scientific Computing, 2015
In this paper, we consider the computation in parallel of several entries of the inverseof a large sparse matrix. We assume that the matrix has already been factorized by a direct methodand that the factors are distributed. Entries are efficiently computed by exploiting sparsity of theright-hand sides and the solution vectors in the triangular solution
Amestoy, Patrick, Duff, Iain S., L'Excellent, Jean-Yves, Rouet, François-Henry   +3 more
openaire   +5 more sources

Thermostable neutral metalloprotease from Geobacillus sp. EA1 does not share thermolysin's preference for substrates with leucine at the P1′ position

FEBS Letters, EarlyView.
Knowing how proteases recognise preferred substrates facilitates matching proteases to applications. The S1′ pocket of protease EA1 directs cleavage to the N‐terminal side of hydrophobic residues, particularly leucine. The S1′ pocket of thermolysin differs from EA's at only one position (leucine in place of phenylalanine), which decreases cleavage ...
Grant R. Broomfield, Torsten Kleffmann, David J. Saul, Sigurd M. Wilbanks   +3 more
wiley   +1 more source

A Comparative Taxonomy of Parallel Algorithms for RNA Secondary Structure Prediction

Evolutionary Bioinformatics, 2010
RNA molecules have been discovered playing crucial roles in numerous biological and medical procedures and processes. RNA structures determination have become a major problem in the biology context.
Ra'ed M. Al-Khatib, Rosni Abdullah, Nur'Aini Abdul Rashid   +2 more
doaj   +1 more source

Analysis of the spatial layer discrete cosine transform coefficient distribution and its application to rate model for H.264/SVC encoder

The Journal of Engineering, 2014
Knowledge of the discrete cosine transform coefficient distribution (DCT-DIST) is important for the encoder design. For example, rate control relies on this knowledge to estimate a possible bit rate and then decide proper coding parameters before the ...
Szu-Wei Lee
doaj   +1 more source

Exploring the Performance of 3-D Nanosheet FET in Inversion and Junctionless Modes: Device and Circuit-Level Analysis and Comparison

IEEE Access, 2023
In this article, the performance of 3-D nanosheet FET (NS-FET) in inversion (INV) and junctionless (JL) modes is demonstrated and compared at both device and circuit levels.
V. Bharath Sreenivasulu, Aruna Kumari Neelam, Sekhar Reddy Kola, Jawar Singh, Yiming Li   +4 more
doaj   +1 more source

Structural dynamics of the plant hormone receptor ETR1 in a native‐like membrane environment

FEBS Letters, EarlyView.
The present study unveils the structural and signaling dynamics of ETR1, a key plant ethylene receptor. Using an optimized nanodisc system and solution NMR, we captured full‐length ETR1 in a native‐like membrane environment. Our findings reveal dynamic domain uncoupling and Cu(I)‐induced rigidification, providing the first evidence of metal‐triggered ...
Moritz Lemke, Nils Alexander Lakomek, Georg Groth   +2 more
wiley   +1 more source

Randomized parallel computation [PDF]

, 1987
The subject of this thesis is randomized parallel algorithms. The goal is to demonstrate the power of randomization in designing efficient parallel algorithms for various computational problems. The specific problems we are concerned with are: sorting, routing, and combinatorial optimization.
Sanguthevar Rajasekaran, John H. Reif
openaire   +2 more sources

Imeglimin attenuates liver fibrosis by inhibiting vesicular ATP release from hepatic stellate cells

FEBS Letters, EarlyView.
Imeglimin, at clinically relevant concentrations, inhibits vesicular ATP accumulation and release from hepatic stellate cells, thereby attenuating purinergic signaling and reducing fibrogenic activation. This mechanism reveals a newly identified antifibrotic action of imeglimin beyond glycemic control.
Seiji Nomura, Lixiang Wang, Nao Hasuzawa, Ayako Nagayama, Sawako Moriyama, Kenji Ashida, Yoshinori Moriyama, Masatoshi Nomura, Ken Yamamoto   +8 more
wiley   +1 more source

A Case for Security-Aware Design-Space Exploration of Embedded Systems

Journal of Low Power Electronics and Applications, 2020
As modern embedded systems are becoming more and more ubiquitous and interconnected, they attract a world-wide attention of attackers and the security aspect is more important than ever during the design of those systems.
Andy D. Pimentel
doaj   +1 more source