Results 71 to 80 of about 1,153,869 (291)

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Temperature-Dependent Hydrogen Modulations of Ultra-Scaled a-IGZO Thin Film Transistor Under Gate Bias Stress

IEEE Open Journal of Nanotechnology
Recently, a-IGZO has advanced toward the next-generation electronics system because of its compatibility with complementary metal oxide semiconductor (CMOS) and back-end-of-line (BOEL) based systems. A systematic electrical characterization of a-IGZO TFT
Muhammad Aslam, Shu-Wei Chang, Min-Hui Chuang, Yi-Ho Chen, Yao-Jen Lee, Yiming Li   +5 more
doaj   +1 more source

Simple parallel and distributed algorithms for spectral graph sparsification

, 2014
We describe a simple algorithm for spectral graph sparsification, based on iterative computations of weighted spanners and uniform sampling. Leveraging the algorithms of Baswana and Sen for computing spanners, we obtain the first distributed spectral ...
Jonathan, Koutis Ioannis, Koutis Ioannis, Livne Oren E., Peng Richard   +4 more
core   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Electrical Characteristics of ML and BL MoS₂ GAA NS FETs With Source/Drain Metal Contacts

IEEE Journal of the Electron Devices Society
This paper reports source/drain (S/D) contact issues in monolayer and bilayer (BL) $\mathrm {MoS_{2}}$ devices through density-functional-theory (DFT) calculation and device simulation.
Yueh-Ju Chan, Min-Hui Chuang, Yiming Li
doaj   +1 more source

Transductive Nonnegative Matrix Tri-Factorization

IEEE Access, 2020
Nonnegative matrix factorization (NMF) decomposes a nonnegative matrix into the product of two lower-rank nonnegative matrices. Since NMF learns parts-based representation, it has been widely used as a feature learning component in many fields.
Xiao Teng, Long Lan, Xiang Zhang, Guohua Dong, Zhigang Luo   +4 more
doaj   +1 more source

Massively parallel computing on an organic molecular layer

, 2010
Current computers operate at enormous speeds of ~10^13 bits/s, but their principle of sequential logic operation has remained unchanged since the 1950s.
A Bandyopadhyay, A Bandyopadhyay, A Credi, A Hjelmfelt, A Imre, A Kirakosian, A Korobov, AJ Ruben, Anirban Bandyopadhyay, AO Orlov, AP Silva, AR Pease, C Dri, CS Lent, Daisuke Fujita, E Fredkin, F Cunha, F Jiménez Morales, Ferdinand Peper, H Qi, J Chen, JJ Hopfield, JP Crutchfeld, JV Neumann, L Onsagar, MA Nowak, R Jones, R Landauer, R Pati, Ranjit Pati, RJ Gaylord, S Wolfram, Satyajit Sahu, T Higuchi, T Müller, T Toffoli, Y Benenson   +36 more
core   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source