Results 91 to 100 of about 2,988,978 (309)
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
High Throughput Computing (SC '08 Education Program's Workshop on Parallel & Cluster Computing)
, 2008 Dr. Henry Neeman, Director OU Supercomputing Center for Education & Research University of Oklahoma SC08 Education Program’s Workshop on Parallel & Cluster Computing August 10-16 2008OUTLINE: -----What is High Throughput Computing?
Neeman, Henry
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Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Accelerated preprocessing of large numbers of brain images by parallel computing on supercomputers. [PDF]
Sci Rep, 2023 Jimbo T +8 more
europepmc +1 more source
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source
Parallel computing in Asian option pricing
, 2007 We discuss the use of parallel computing in Asian option pricing and evaluate the efficiency of various algorithms. We only focus on "backward-starting fixed strike" Asian options that are continuously averaged.
Sak, Halis +2 more
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High-Performance 3D Compressive Sensing MRI Reconstruction Using Many-Core Architectures
International Journal of Biomedical Imaging, 2011 Compressive sensing (CS) describes how sparse signals can be accurately reconstructed from many fewer samples than required by the Nyquist criterion.
Daehyun Kim +5 more
doaj +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Efficient parallel computing with a compact finite difference scheme
, 2012 This paper proposes an efficient parallel computing approach based on a high-order accurate compact finite difference scheme in conjunction with a conventional domain decomposition method and MPI libraries.
Kim, J.W., Sandberg, R.D.
core +1 more source
Intelligent Modelling of the Real Dynamic Viscosity of Rubber Blends Using Parallel Computing. [PDF]
Polymers (Basel), 2023 Kopal I +5 more
europepmc +1 more source