Results 111 to 120 of about 2,988,978 (309)

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

open access: yesMolecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee   +3 more
wiley   +1 more source

Overview of Parallelism (SC '08 Education Program's Workshop on Parallel & Cluster Computing)

open access: yes, 2008
Dr. Henry Neeman, Director OU Supercomputing Center for Education & Research University of Oklahoma SC08 Education Program’s Workshop on Parallel & Cluster computing August 10-16 2008OUTLINE: ----Parallelism ----The Jigsaw Puzzle Analogy for ...
Neeman, Henry
core  

Simultaneously Estimating Process Variation Effect, Work Function Fluctuation, and Random Dopant Fluctuation of Gate-All-Around Silicon Nanosheet Complementary Field-Effect Transistors

open access: yesNanomaterials
We systematically investigate the combined impact of process variation effects (PVEs), metal gate work function fluctuation (WKF), and random dopant fluctuation (RDF) on the key electrical characteristics of sub-1-nm technology node gate-all-around ...
Sekhar Reddy Kola, Yiming Li
doaj   +1 more source

A role for eIF5A in translational control of stress‐inducible proteins in multiple myeloma cell lines

open access: yesMolecular Oncology, EarlyView.
Loss of eIF5A rewires thapsigargin‐mediated endoplasmic reticulum stress responses in multiple myeloma cells by selective translation of mRNA transcripts, consequently dampening thapsigargin‐induced unfolded protein response (UPR) activation and shifting the balance from induction of apoptosis toward cell survival and proliferation.
Demi Both   +7 more
wiley   +1 more source

Grab Bag: Scientific Libraries, I/O Libraries, Visualization (SC '08 Education Program's Workshop on Parallel & Cluster Computing)

open access: yes, 2008
Dr. Henry Neeman, Director OU Supercomputing Center for Education & Research University of Oklahoma SC08 Education Program’s Workshop on Parallel & Cluster Computing August 10-16 2008OUTLINE: ----Scientific Computing Pipeline ----Scientific ...
Neeman, Henry
core  

NAPRT loss promotes lung tumor initiation and growth through AKT signaling independently of NAD+ biosynthesis

open access: yesMolecular Oncology, EarlyView.
Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh   +11 more
wiley   +1 more source

A Parallel Variant of the Gram-Schmidt Process with Reorthogonalization

open access: yes, 2006
[EN] This work is concerned with the effective parallelization of algorithms for computing an orthonormal basis of a subspace in the context of Krylov-type eigenvalue solvers such as Arnoldi.
Tomás Domínguez, Andrés Enrique   +2 more
core  

Speedup for Multi-Level Parallel Computing

open access: yes, 2012
This paper studies the speedup for multi-level parallel computing. Two models of parallel speedup are considered, namely, fixed-size speedup and fixed-time speedup.
Tang, Shanjiang   +5 more
core   +1 more source

Analysis and Solutions to 3G Gateway Issues in Agriculture WSNs

open access: yesInternational Journal of Distributed Sensor Networks, 2015
Wireless sensor networks (WSN) are used extensively in various important areas of agriculture. Many of the associated activities involve the transmission of data or control commands through gateways that connect the servers to 3G networks. In this paper,
Zhihui Ge, Wei Liu, Tao Shen Li, Jin Ye
doaj   +1 more source

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