Results 131 to 140 of about 2,988,978 (309)

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Nonlinear Optimization and Parallel Computing

, 2003
The new computational technologies are having a very strong influence on numerical optimization, in several different ways. Many researchers have been stimulated by the need to either conform the existing numerical techniques to the new parallel ...
MIGDALAS A., TORALDO, GERARDO, KUMAR V., Kumar, Vipin P.,, Toraldo, Gerardo,, Migdalas, Athanasios,   +5 more
core   +1 more source

Multitask Vehicle Signal Recognition With Dual-Speed Adaptive Weighting

Journal of Advanced Transportation
In mixed traffic environments, the accurate identification of vehicular devices’ modulation schemes, communication protocols, and emitter device information directly affects perception capabilities toward surrounding vehicles and infrastructure. However,
Dianjing Cheng, Xiangyu Shi, Zhihua Cui, Xingyu Wu, Wenjia Niu   +4 more
doaj   +1 more source

3DMeshNet: A three-dimensional differential neural network for structured mesh generation

Graphical Models
Mesh generation is a crucial step in numerical simulations, significantly impacting simulation accuracy and efficiency. However, generating meshes remains time-consuming and requires expensive computational resources.
Jiaming Peng, Xinhai Chen, Jie Liu
doaj   +1 more source

Slicing Algorithm and Partition Scanning Strategy for 3D Printing Based on GPU Parallel Computing. [PDF]

Materials (Basel), 2021
Lai X, Wei Z.
europepmc   +1 more source

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

Molecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David, Arthur Karaulic, Audrey Bennetot, Clémence Fournier, Quentin Odet, Arthur Gouraud, Isabelle Bourget, Cédric Gaggioli, Sandy Giuliano, Frédéric Luciano, Olivier Léger, Zaki Sellam, Gilles Pagès   +12 more
wiley   +1 more source

Fast parallel Markov clustering in bioinformatics using massively parallel computing on GPU with CUDA and ELLPACK-R sparse format

, 2012
Markov clustering (MCL) is becoming a key algorithm within bioinformatics for determining clusters in networks. However, with increasing vast amount of data on biological networks, performance and scalability issues are becoming a critical limiting ...
Hamilton, Nicholas A., Burrage, Kevin, Bustamam, Alhadi, Hamilton, Nicolas A.   +3 more
core   +1 more source

Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

Molecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source

A Parallel Computing Approach to Spatial Neighboring Analysis of Large Amounts of Terrain Data Using Spark. [PDF]

Sensors (Basel), 2021
Zhang J, Ye Z, Zheng K.
europepmc   +1 more source

Tumour‐proximal deep serum proteomics identifies biomarkers associated with ovarian cancer

Molecular Oncology, EarlyView.
New biomarkers are needed for early ovarian cancer detection. Ovarian (tumour‐proximal) and peripheral vein serum from healthy women and patients with benign or malignant tumours underwent nanoparticle‐enriched deep proteomics. Ovarian serum yielded more protein identifications and revealed tumour‐reflective signatures.
Darren Lau, Daniel Pincher, Clifford Young, Nicholas Chappell, Noor A. Lokman, Parul Mittal, Leigh Donnellan, Martin K. Oehler, Doug A. Brooks, Peter Hoffmann   +9 more
wiley   +1 more source