Results 151 to 160 of about 4,923,689 (361)

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Transport Codes and Shifting (SC '08 Education Program's Workshop on Parallel & Cluster Computing)

, 2008
Dr. Henry Neeman, Director OU Supercomputing Center for Education & Research University of Oklahoma SC08 Education Program’s Workshop on Parallel & Cluster computing August 10-16 2008What is a Simulation: All physical science ultimately is expressed
Neeman, Henry
core  

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

TREE-PUZZLE: maximum likelihood phylogenetic analysis using quartets and parallel computing

Bioinform., 2002
H. Schmidt, K. Strimmer, M. Vingron, A. Haeseler   +3 more
semanticscholar   +1 more source

CLAIRE: Constrained Large Deformation Diffeomorphic Image Registration on Parallel Computing Architectures. [PDF]

J Open Source Softw, 2021
Brunn M, Himthani N, Biros G, Mehl M, Mang A.   +4 more
europepmc   +1 more source

A Performance-Based Parallel Loop Self-Scheduling on Grid Environments

, 2009
[[abstract]]The effectiveness of loop self-scheduling schemes has been shown on traditional multiprocessors in the past and computing clusters in the recent years.
Wen-Chung Shih; Chao-Tung Yang; S. S. Tseng
core  

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

Multitask Vehicle Signal Recognition With Dual-Speed Adaptive Weighting

Journal of Advanced Transportation
In mixed traffic environments, the accurate identification of vehicular devices’ modulation schemes, communication protocols, and emitter device information directly affects perception capabilities toward surrounding vehicles and infrastructure. However,
Dianjing Cheng, Xiangyu Shi, Zhihua Cui, Xingyu Wu, Wenjia Niu   +4 more
doaj   +1 more source

Lectures on Parallel Computing

CoRR
These lecture notes are designed to accompany an imaginary, virtual, undergraduate, one or two semester course on fundamentals of Parallel Computing as well as to serve as background and reference for graduate courses on High-Performance Computing, parallel algorithms and shared-memory multiprocessor programming. They introduce theoretical concepts and
openaire   +2 more sources

On the reliability and energy efficiency in cloud computing

, 2015
With the popularity of cloud computing, it becomes crucial to provide on-demand services dynamically according to the user’s requirements. Reliability and energy efficiency are two big challenges in cloud computing systems that need careful attention and
Javadi, Bahman (R17034), Si, Weisheng (R16985), Sharma, Yogesh (S32158)   +2 more
core