Results 61 to 70 of about 1,153,869 (291)

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Systematic Analysis of Low-Precision Training in Deep Neural Networks: Factors Influencing Matrix Computations

Applied Sciences
As Deep Neural Networks (DNNs) continue to increase in complexity, the computational demands of their training have become a significant bottleneck. Low-precision training has emerged as a crucial strategy, wherein full-precision values are quantized to ...
Ao Shen, Zhiquan Lai, Lizhi Zhang
doaj   +1 more source

A Formal Model For Real-Time Parallel Computation

, 2012
The imposition of real-time constraints on a parallel computing environment- specifically high-performance, cluster-computing systems- introduces a variety of challenges with respect to the formal verification of the system's timing properties.
Chikkagoudar, Satish, Hui, Peter
core   +2 more sources

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Multibody Dynamics Model of a Human Hand for Haptics Interaction [PDF]

, 2008
In this paper we propose a strategy for modelling a human hand for Haptics interaction. The strategy consists in a parallel computing architecture that calculates the dynamics of a hand; this is accomplished by computing the dynamics of each finger in a ...
Aracil Santonja, Rafael, Carrera Calderon, Isela Guadalupe, Ferre Pérez, Manuel, Moreno Avalos, Hector, Saltaren Pazmiño, Roque Jacinto, Yime, Eugenio   +5 more
core   +1 more source

HSTREAM: A directive-based language extension for heterogeneous stream computing

, 2018
Big data streaming applications require utilization of heterogeneous parallel computing systems, which may comprise multiple multi-core CPUs and many-core accelerating devices such as NVIDIA GPUs and Intel Xeon Phis.
Memeti, Suejb, Pllana, Sabri
core   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

PFASUM: a substitution matrix from Pfam structural alignments

BMC Bioinformatics, 2017
Background Detecting homologous protein sequences and computing multiple sequence alignments (MSA) are fundamental tasks in molecular bioinformatics. These tasks usually require a substitution matrix for modeling evolutionary substitution events derived ...
Frank Keul, Martin Hess, Michael Goesele, Kay Hamacher   +3 more
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

PkMin: Peak Power Minimization for Multi-Threaded Many-Core Applications

Journal of Low Power Electronics and Applications, 2020
Multiple multi-threaded tasks constitute a modern many-core application. An accompanying generic Directed Acyclic Graph (DAG) represents the execution precedence relationship between the tasks.
Arka Maity, Anuj Pathania, Tulika Mitra
doaj   +1 more source