Results 61 to 70 of about 2,988,978 (309)

Systematic Analysis of Low-Precision Training in Deep Neural Networks: Factors Influencing Matrix Computations

Applied Sciences
As Deep Neural Networks (DNNs) continue to increase in complexity, the computational demands of their training have become a significant bottleneck. Low-precision training has emerged as a crucial strategy, wherein full-precision values are quantized to ...
Ao Shen, Zhiquan Lai, Lizhi Zhang
doaj   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Advances in parallel and distributed computing and its applications

, 2021
Parallel and distributed computing has been the basis to many emerging areas, such as smart networks, cloud computing, big data analysis, and blockchain technology.
Alan Wee‐Chung Liew, Hong Shen, Hui Tian, Shen, Hong, Liew, Alan Wee-Chung, Tian, Hui   +5 more
core   +1 more source

A Case for Security-Aware Design-Space Exploration of Embedded Systems

Journal of Low Power Electronics and Applications, 2020
As modern embedded systems are becoming more and more ubiquitous and interconnected, they attract a world-wide attention of attackers and the security aspect is more important than ever during the design of those systems.
Andy D. Pimentel
doaj   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Chiral separation of chloroalkanes with the chromatographic column onboard Martian rovers

FEBS Letters, EarlyView.
Computer image of the Rosalind Franklin Rover of ESA's ExoMars mission. ExoMars is scheduled to land on planet Mars in Oxia Planum in 2029. This area represents an interesting spot to look for biosignatures. Investigations of ExoMars include measurement on molecular chirality. We show that chiral chloroalkanes, that have been identified on Mars, can be
Asma Merzougui, Agnes Banreti, Armelle L. Ernst, Guillaume Leseigneur, Uwe J. Meierhenrich   +4 more
wiley   +1 more source

BlueCube:Constructing a Hypercube Parallel Computing and Communication Environment over Bluetooth Radio Systems

, 2003
In existing parallel computing structures, hypercubes have several distinct advantages; they support parallel computing, provide disjoint path and tolerate faults. If devices with computing capabilities can be linked as a hypercube by taking advantage of
Chang, Chao-tsun; 張志勇; Chnag, Chih-yung; Sheu, Jang-ping, Chih-Yung Chang, Chao-Tsun Chang, Jang-Ping Sheu   +3 more
core   +1 more source

Geometry-Dependent Current Injection Mechanisms and Contact Length Scaling in p-Type WSe₂ Field-Effect Transistors

IEEE Access
This work investigates the impact of source/drain (S/D) contact geometry on carrier injection mechanisms and contact scalability in p-type monolayer (ML) WSe2 field-effect transistors (FETs).
Szu-Huan Hsu, Yiming Li
doaj   +1 more source

PFASUM: a substitution matrix from Pfam structural alignments

BMC Bioinformatics, 2017
Background Detecting homologous protein sequences and computing multiple sequence alignments (MSA) are fundamental tasks in molecular bioinformatics. These tasks usually require a substitution matrix for modeling evolutionary substitution events derived ...
Frank Keul, Martin Hess, Michael Goesele, Kay Hamacher   +3 more
doaj   +1 more source