Results 61 to 70 of about 329,729 (302)

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Recurrent Modification of a Conserved Cis-Regulatory Element Underlies Fruit Fly Pigmentation Diversity [PDF]

, 2013
The development of morphological traits occurs through the collective action of networks of genes connected at the level of gene expression. As any node in a network may be a target of evolutionary change, the recurrent targeting of the same node would ...
Salomone, Joseph R., Joseph R Salomone, Williams, Thomas M., William A. Rogers (451944), Camino, Eric M., Davis, Kristen A., Kristen A Davis, Joseph R. Salomone (451945), Rebeiz, M, Eric M. Camino (451947), David J Tacy, Williams, TM, Davis, KA, Mark Rebeiz (451949), Thomas M. Williams (10343), Rogers, William A., Tacy, David J., Rebeiz, Mark, Rogers, WA, Eric M Camino, Camino, EM, Levine, Michael, Kristen A. Davis (451948), Tacy, DJ, David J. Tacy (451946), Salomone, JR, William A Rogers, Mark Rebeiz, Thomas M Williams   +28 more
core   +1 more source

Chemodiversity in Selaginella: a reference system for parallel and convergent metabolic evolution in terrestrial plants

Frontiers in Plant Science, 2013
Early plants began colonizing the terrestrial earth approximately 450 million years ago. Their success on land has been partially attributed to the evolution of specialized metabolic systems from core metabolic pathways, the former yielding structurally ...
Jing-Ke eWeng, Joseph P. Noel
doaj   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Initial mutations direct alternative pathways of protein evolution

, 2011
Whether evolution is erratic due to random historical details, or is repeatedly directed along similar paths by certain constraints, remains unclear. Epistasis (i.e.
J Arjan G M de Visser, Tawfik Dan S., Salverda, M.L.M., Merijn L M Salverda, Hoekstra, R.F., Salverda Merijn L. M., Dellus, E., John van der Oost, Alfons J M Debets, Visser, J.A.G.M., de, Gorter Florien A., de Visser J. Arjan G. M., Florien A Gorter, Dellus Eynat, Dan S Tawfik, Gorter, F.A., Debets Alfons J. M., van der Oost John, Eynat Dellus, Hoekstra Rolf F., Debets, A.J.M., Oost, J., van der, J. Arjan G. M. de Visser, Merijn L. M. Salverda, Tawfik, D.S., Florien A. Gorter, Alfons J. M. Debets, Rolf F Hoekstra, de Visser, J.A.G.M., van der Oost, J., Rolf F. Hoekstra, Dan S. Tawfik   +31 more
core   +1 more source

Modular chromosome rearrangements reveal parallel and nonparallel adaptation in a marine fish

Ecology and Evolution, 2020
Genomic architecture and standing variation can play a key role in ecological adaptation and contribute to the predictability of evolution. In Atlantic cod (Gadus morhua), four large chromosomal rearrangements have been associated with ecological ...
Tony Kess, Paul Bentzen, Sarah J. Lehnert, Emma V. A. Sylvester, Sigbjørn Lien, Matthew P. Kent, Marion Sinclair‐Waters, Corey Morris, Brendan Wringe, Robert Fairweather, Ian R. Bradbury   +10 more
doaj   +1 more source

Domain-Dependent Evolution Explains Functional Homology of Protostome and Deuterostome Complement C3-Like Proteins

Frontiers in Immunology, 2022
Complement proteins emerged early in evolution but outside the vertebrate clade they are poorly characterized. An evolutionary model of C3 family members revealed that in contrast to vertebrates the evolutionary trajectory of C3-like genes in cnidarian ...
Maoxiao Peng, Maoxiao Peng, Zhi Li, Zhi Li, João C. R. Cardoso, Donghong Niu, Donghong Niu, Donghong Niu, Xiaojun Liu, Zhiguo Dong, Jiale Li, Jiale Li, Jiale Li, Deborah M. Power, Deborah M. Power   +14 more
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Pool Evolution: A Parallel Pattern for Evolutionary and Symbolic Computing [PDF]

, 2016
We introduce a new parallel pattern derived from a specific application domain and show how it turns out to have application beyond its domain of origin.
Kilpatrick, Peter; id_orcid, Kilpatrick, Peter, Aldinucci, Marco, Campa, Sonia, Danelutto, Marco, Torquati, Massimo   +5 more
core   +1 more source