Results 231 to 240 of about 1,547,357 (293)

From mitochondrial zonation to immune dysregulation: a mechanistic axis in diabetic cardiomyopathy. [PDF]

Front Cardiovasc Med
Chen J, Fu L, Zhang J, Ding R, Zhang H, Xu G, Hu J, Yang P.   +7 more
europepmc   +1 more source

Degrading GPX4 via Biomimetic Nanoparticle‐Mediated In Situ Synthesis of Deep‐Learning‐Designed Binder‐Degron Chimeras for Prostate Cancer Therapy

Advanced Science, EarlyView.
A deep‐learning‐designed binder is fused to a combinatorial degron to create a binder‐degron chimera (bdC) that recruits the CUL2‐RING ubiquitin ligase complex. Encapsulation in a prostate‐cancer‐targeted, CD47‐camouflaged nanocarrier enables tumor‐specific in situ bdC expression, triggering GPX4 degradation and ferroptosis, thereby establishing a ...
Si‐Han Zhang, Ye An, Na Zeng, Mei‐Cheng Liu, Jian‐Xuan Sun, Xi Gong, Jin‐Zhou Xu, Shao‐Gang Wang, Qi‐Dong Xia   +8 more
wiley   +1 more source

From aid dependency to market transformation: harnessing international trade and innovative business models to revitalize the assistive technology ecosystem in Africa. [PDF]

Front Rehabil Sci
Pakouyowou MT.
europepmc   +1 more source

Curvature‐Directed Elongation and Chiral Tilting Drive Asymmetric Tissue Patterning

Advanced Science, EarlyView.
Curvature and cell handedness together break tissue symmetry. On convex and concave surfaces, cells elongate along opposite geometric axes and tilt in a consistent chirality‐driven direction, yielding opposite alignment patterns from the same cells. Reversing intrinsic cell chirality reverses both.
Liyao Xu, Frank Daniel Peters, Haokang Zhang, Madison Stiefbold, Thangam Ramar, Aditya Agarwal, Leo Q. Wan   +6 more
wiley   +1 more source

Global trade responses to shark finning regulations. [PDF]

Nat Commun
Burns ES, Orofino S, Wang K, Bradley D, D'Costa NG, Feitosa LM, Schiller L, Worm B, Gephart JA, McDonald GG.   +9 more
europepmc   +1 more source

Oral Recombinant Human Collagen III Protects Gastric Mucosa via G‐Quadruplex‐Mediated Activation of the Pla2g4a‐Prostaglandin Axis

Advanced Science, EarlyView.
Orally administered recombinant human type III collagen protects the gastric mucosa from ethanol‐induced injury by coordinating redox homeostasis, epithelial barrier repair, and arachidonic acid–prostaglandin metabolism. Gastric digestion releases the pentapeptide GPAEF, which interacts with the Pla2g4a promoter G‐quadruplex in a structure‐dependent ...
Xinyue Lan, Qiu Dai, Yanhui Wang, Jiaxuan Gu, Chengyun Wang, Weicheng Xu, Xinru Gao, Jiageng Cheng, Wentao Geng, Xiaowen Wu, Haihang Li, Xiaoyun He, Shengwei Fu, Longjiao Zhu, Wentao Xu   +14 more
wiley   +1 more source

Transmembrane domain switching controls PINK1 import and fate in mitochondria. [PDF]

EMBO J
Lorriman JS, Hughes RJ, Grieve AG, Corey RA, Collinson I.   +4 more
europepmc   +1 more source

The Impact of US Food and Drug Administration's Advisory and Enforcement Actions on US Sales of Esco Bars Products in 2023: Synthetic Control Approach. [PDF]

JMIR Public Health Surveill
Shin H, Hannings J, Cahn Z, Xu X, Toblin R, Farrelly M, King BA.   +6 more
europepmc   +1 more source

Mitochondrial Quality Control and Pathogenic Signaling Networks in Parkinson's Disease. [PDF]

Curr Issues Mol Biol
Zhang X, Li H, Zhao J, Tang J, Li X, Li P, Zhao Q, Wang Q, Zou W.   +8 more
europepmc   +1 more source

ABPs: diffusible antibacterial toxins secreted by and active against diverse gram-positive bacteria. [PDF]

Infect Immun
Colautti J, Mwangi D, Woodward JJ, Whitney JC.   +3 more
europepmc   +1 more source