Results 111 to 120 of about 1,738,675 (258)
Molecular Oncology, EarlyView.The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim +17 more
wiley +1 more source
Decentralised Parallel Machine Scheduling for Multi-Agent Task Allocation
, 2011 Multi-agent task allocation problems pervade a wide range of real-world applications, such as search and rescue in disaster management, or grid computing.
Vinyals, Meritxell +9 more
core +1 more source
Eine Labor-Parallelkinematik mit 6 Freiheitsgraden zur Evaluation neuer Methoden
, 2022 S.871-878In the past, many methodical scientific activities on parallel kinematic machines found results that could be generalised for conventional machine concepts as well.
Krabbes, M. +3 more
core +1 more source
Versatile vector tools for efficient protein screening across multiple expression systems
FEBS Open Bio, EarlyView.A unified vector toolkit enables rapid protein expression screening across E. coli, insect, and mammalian cells. A single primer pair amplifies the target gene, which is inserted into any vector via a standardized interface. This streamlined workflow eliminates repeated cloning steps, accelerating the identification of optimal expression conditions for
Zhimin Zhu +5 more
wiley +1 more source
A layered approach to parallel software performance prediction : a case study [PDF]
An approach to the characterisation of parallel systems using a structured layered methodology is described here. The aim of this is to produce accurate performance predictions which maybe used to influence the choice of machines and investigate ...
Nudd, G. R. +2 more
core
Directed evolution of enzymes at the crossroads of tradition and innovation
FEBS Open Bio, EarlyView.An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova +2 more
wiley +1 more source
Machine Scheduling with Resource Dependent Processing Times [PDF]
We consider several parallel machine scheduling settings with the objective to minimize the schedule makespan. The most general of these settings is unrelated parallel machine scheduling.
Sviridenko,Maxim +2 more
core
FEBS Open Bio, EarlyView.The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley +1 more source
Characterisation based bottleneck analysis of parallel systems [PDF]
Bottleneck analysis plays an important role in the early design of parallel computers and programs. In this paper a methodology for bottleneck analysis based on an instruction level characterisation technique is presented. The methodology is based on the
Nudd, G. R., Zemerly, M. J., Papay, J.
core
Malformin A1–mediated cytotoxicity in ovarian cancer cells occurs through pyroptosis and autophagy
FEBS Open Bio, EarlyView.This study investigated the effects of the natural compound Malformin A1 (MA1) on the cytoskeleton that regulates cell proliferation and migration. Disruption of the cytoskeleton can impair these processes and promote cancer cell death. MA1 disrupted cytoskeletal organization, induced DNA damage, inflammation, activated autophagy, and pyroptosis ...
Nada Abdullah Hassan +11 more
wiley +1 more source