Results 101 to 110 of about 1,738,675 (258)
ADP‐ribosylation: An emerging regulator of the epigenome
Molecular Oncology, EarlyView.ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho +2 more
wiley +1 more source
Parallel decomposition approaches for training support vector machines
, 2004 We consider parallel decomposition techniques for solving the large quadratic programming (QP) problems arising in training support vector machines. A recent technique is improved by introducing an efficient solver for the inner QP subproblems and a ...
ZANNI L. +2 more
core +2 more sources
Scientific ReportsThis paper addresses a hybrid processing system in automotive mold casting, which involves single processing machines and parallel batch processing machines.
Hanpeng Wang +3 more
doaj +1 more source
MAPSkew: Metaheuristic Approaches for Partitioning Skew in MapReduce
Algorithms, 2018 MapReduce is a parallel computing model in which a large dataset is split into smaller parts and executed on multiple machines. Due to its simplicity, MapReduce has been widely used in various applications domains.
Matheus H. M. Pericini +4 more
doaj +1 more source
Molecular Oncology, EarlyView.We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee +3 more
wiley +1 more source
Sukkur IBA Journal of Computing and Mathematical Sciences, 2017 In last decade, application developers attained improved performances by merely employing the machines based on higher-clocked processors. However, in 2003 multi-core processors emerged and eradicated the old processor manufacturing technology based on ...
Badri Munier +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley +1 more source
Scheduling Parallel Jobs with Linear Speedup [PDF]
We consider a scheduling problem where a set of jobs is distributed over parallel machines. The processing time of any job is dependent on the usage of a scarce renewable resource, e.g., personnel.
Grigoriev,Alexander, Uetz,Marc
core
Space exploration using parallel orbits:A study in parallel symbolic computing [PDF]
, 2013 Orbit enumerations represent an important class of mathematical algorithms which is widely used in computational discrete mathematics. In this paper, we present a new shared-memory implementation of a generic Orbit skeleton in the GAP computer algebra ...
Brown, Christopher Mark +11 more
core +1 more source
Molecular Oncology, EarlyView.Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez +5 more
wiley +1 more source