Results 81 to 90 of about 1,738,675 (258)
Local search performance guarantees for restricted related parallel machine scheduling [PDF]
We consider the problem of minimizing the makespan on restricted related parallel machines. In restricted machine scheduling each job is only allowed to be scheduled on a subset of machines. We study the worst-case behavior of local search algorithms. In
Recalde Diego +3 more
core
MathematicsThis study addresses the multi-period, multi-item, single-stage capacitated lot sizing problem (CLSP) in a parallel machine environment with machine eligibility constraints under a make-to-order production policy. A mixed-integer linear programming (MILP)
Felipe T. Muñoz, Juan Ulloa-Navarro
doaj +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Solving Lotsizing Problems on Parallel Identical Machines Using Symmetry Breaking Constraints [PDF]
Production planning on multiple parallel machines is an interesting problem, both from a theoretical and practical point of view. The parallel machine lotsizing problem consists of finding the optimal timing and level of production and the best ...
Jans, R.F.
core
Applied SciencesThe cloud manufacturing (CMfg) platform serves as a centralized hub for allocating and scheduling tasks to distributed resources. It features a concrete two-agent model that addresses real-world industrial needs: the first agent handles long-term ...
Xin Xin, Suxia Zhou, Jinsheng Gao
doaj +1 more source
The Distributed Assembly Parallel Machine Scheduling Problem with eligibility constraints.
International Journal of Production Management and Engineering, 2015 In this paper we jointly consider realistic scheduling extensions: First we study the distributed unrelated parallel machines problems by which there is a set of identical factories with parallel machines in a production stage.
Sara Hatami +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park +6 more
wiley +1 more source
Translating whole‐genome doubling into precision medicine in cancer
Molecular Oncology, EarlyView.Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley +1 more source
Advances in Mechanical Engineering, 2017 Static performance evaluation is one of the most important issues during the design stage of tripod parallel kinematic machines. Taken the 1T2R tripods as examples, this article proposes two improved static performance indices, namely, local dexterity ...
Jun Zhang, Hanliang Fang, Tengfei Tang
doaj +1 more source
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source