Results 71 to 80 of about 48,711 (267)
Directed evolution of enzymes at the crossroads of tradition and innovation
FEBS Open Bio, EarlyView.An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova +2 more
wiley +1 more source
FEBS Open Bio, EarlyView.The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley +1 more source
Malformin A1–mediated cytotoxicity in ovarian cancer cells occurs through pyroptosis and autophagy
FEBS Open Bio, EarlyView.This study investigated the effects of the natural compound Malformin A1 (MA1) on the cytoskeleton that regulates cell proliferation and migration. Disruption of the cytoskeleton can impair these processes and promote cancer cell death. MA1 disrupted cytoskeletal organization, induced DNA damage, inflammation, activated autophagy, and pyroptosis ...
Nada Abdullah Hassan +11 more
wiley +1 more source
IEEE AccessThis paper suggests a technique to reduce noise in DC current measurements within an integrated power conversion system, which includes a three-phase inverter and a full-bridge converter both utilizing single shunt resistors as current sensors. Typically,
Ju-An Kim, Yong-Gyu Cho, Hyeon-Gyu Choi
doaj +1 more source
Advances in Mechanical Engineering, 2018 We study an agent-based scheduling problem of two identical parallel machines: P 2 | Co | ∑ T A , C max B . The machines and tasks are regarded as agents.
Fei Yu, Peihan Wen, Shuping Yi
doaj +1 more source
International Journal of Technology, 2015 Most classical scheduling approaches deal with single products, single machines, and static manufacturing environments. In real-world manufacturing systems, however, scheduling can be assigned for multi-item production on multimachines in a dynamic ...
Isti Surjandari +3 more
doaj +1 more source
ATZ‐1 promotes DNA replication efficiency to maintain normal meiotic function
FEBS Open Bio, EarlyView.Absence of ATZ‐1 interferes with meiotic DNA replication and cell cycle function via CHK‐1. This causes downstream defects associated with DNA damage and genomic integrity. Taken together, this study suggests that ATZ‐1 influences DNA replication efficiency and cell cycle function to maintain normal meiotic function.
Taylin E. Gourley +5 more
wiley +1 more source
MAPSkew: Metaheuristic Approaches for Partitioning Skew in MapReduce
Algorithms, 2018 MapReduce is a parallel computing model in which a large dataset is split into smaller parts and executed on multiple machines. Due to its simplicity, MapReduce has been widely used in various applications domains.
Matheus H. M. Pericini +4 more
doaj +1 more source
Optimizing photoexcitation conditions for time‐resolved X‐ray solution scattering experiments
FEBS Open Bio, EarlyView.Time‐resolved X‐ray solution scattering (TR‐XSS) is a powerful technique to visualize how proteins change their structure in real time after light activation. Selecting the right laser photoexcitation conditions—fluence, excitation geometry, and sample refresh rate—is critical to maximize the experimental signal while avoiding unwanted side effects ...
Matteo Levantino
wiley +1 more source
Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance
Aging and Cancer, EarlyView.NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang +3 more
wiley +1 more source