Results 51 to 60 of about 1,738,675 (258)
Applied SciencesMulti-product production systems require effective coordination among production, intermediate storage, downstream processing, and customer demand, particularly under stochastic operating conditions and finite capacity. Unlike existing analytical studies
Angelos Kourepis +4 more
doaj +1 more source
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
Translophagy—A potential link between autophagy impairment and translational errors
FEBS Letters, EarlyView.Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk +11 more
wiley +1 more source
An Arc-Flow Model for the Makespan Minimization Problem on Identical Parallel Machines
IEEE Access, 2018 In this paper, we consider the basic makespan minimization problem on identical parallel machines. The aim of this study is to solve, to optimality the hard instances of the literature. We present an integer linear program based on an innovative arc-flow
Mehdi Mrad, Nizar Souayah
doaj +1 more source
Structural and biochemical analysis of a B12 superbinder
FEBS Letters, EarlyView.BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices +3 more
wiley +1 more source
GRAph Parallel Actor Language: A Programming Language for Parallel Graph Algorithms [PDF]
, 2013 We introduce a domain-specific language, GRAph Parallel Actor Language, that enables parallel graph algorithms to be written in a natural, high-level form.
DeLorimier, Michael John
core +1 more source
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source
Scalable data abstractions for distributed parallel computations [PDF]
, 2012 The ability to express a program as a hierarchical composition of parts is an essential tool in managing the complexity of software and a key abstraction this provides is to separate the representation of data from the computation.
Hollis, Simon J. +2 more
core
The accuracy of hydraulically driven struts for production machines
, 2022 S.503-516Hydraulic struts in parallel kinematics for production machines can be used to particular advantage if the job is creating large machining forces with sufficient load rigidity.
Noack, S., Neugebauer, Reimund
core +1 more source
Special Issue: Robotics and Parallel Kinematic Machines
RoboticsParallel kinematic machines (PKMs) are a class of robots that have long been recognized for their higher stiffness and high payload-to-weight ratio and precision compared to their serial counterparts [...]
Swaminath Venkateswaran
doaj +1 more source