Results 31 to 40 of about 48,711 (267)
Reciprocal control of viral infection and phosphoinositide dynamics
FEBS Letters, EarlyView.Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley +1 more source
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
FEBS Letters, EarlyView.Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley +1 more source
An Optimization Model for Production Scheduling in Parallel Machine Systems
AxiomsThe efficiency and quality of the manufacturing industry are greatly influenced by production scheduling, which makes it a crucial aspect. A well-designed production scheduling scheme can significantly enhance manufacturing efficiency and reduce ...
Leting Zu, Wenzhu Liao, Xiaoxia Yang
doaj +1 more source
Journal of Membrane ComputingAbstractWithin the branch of Natural Computing, several models or types of computation arise, some of them are well-established such as neural networks, evolutionary computing or membrane computing, while others have yet to be studied and developed.
Antonio Ramírez-de-Arellano +2 more
openaire +2 more sources
Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis
FEBS Letters, EarlyView.Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee +7 more
wiley +1 more source
Presenting a model for scheduling parallel machines considering divisible tasks, and preparation time by reduction of energy cost [PDF]
مدیریت مهندسی و رایانش نرمScheduling parallel machines is an important problem in manufacturing systems, one of the important goals of which is to minimize the completion time, but the goals in this problem are not limited to scheduling and can include costs, including energy ...
Samira Sameye +2 more
doaj +1 more source
Speedups of deterministic machines by synchronous parallel machines
Proceedings of the fifteenth annual ACM symposium on Theory of computing - STOC '83, 1983 The paper presents new speedups of deterministic multitape Turing machines by both fixed and variable structure parallel machines. Namely, it is shown that DTIME(T)\(\subseteq ATIME(T/\log T)\) and DTIME(T)\(\subseteq PRAM\)-time(\(\sqrt{T})\). These improve many previously known results.
Patrick W. Dymond, Martin Tompa
openaire +2 more sources
FEBS Letters, EarlyView.Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source