Results 81 to 90 of about 661,672 (286)

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

An implementation of a plasma physics application for distributed-memory supercomputers using a directive-based programming framework

Revista Colombiana de Computación
To extract performance from supercomputers, programmers in the High Performance Computing (HPC) community are often required to use a combination of frameworks to take advantage of the multiple levels of parallelism. However, over the years, efforts have
Christian Asch, Emilio Francesquini, Esteban Meneses   +2 more
doaj   +1 more source

On the Recursive-Parallel Programming for the .NET Framework

Моделирование и анализ информационных систем, 2014
The paper describes software components to support recursive-parallel programming for the .NET Framework. They are dynamic link libraries providing the necessary functionality for developing and debugging applications for parallel execution on a local ...
V. V. Vasilchikov
doaj   +1 more source

Mainstream parallel array programming on cell [PDF]

, 2011
We present the E] compiler and runtime library for the ‘F’ subset of the Fortran 95 programming language. ‘F’ provides first-class support for arrays, allowing E] to implicitly evaluate array expressions in parallel using the SPU coprocessors of the ...
Cockshott, W.P., Keir, P., Richards, A.
core  

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Parallel Computation in Econometrics: A Simplified Approach [PDF]

Parallel computation has a long history in econometric computing, but is not at all wide spread. We believe that a major impediment is the labour cost of coding for parallel architectures.
David F. Hendry, Jurgen A. Doornik, Neil Shephard   +2 more
core  

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Using OpenMP: Portable Shared Memory Parallel Programming

Journal of Computer Science and Technology, 2010
The book Using OpenMP: Portable Shared Memory Parallel Programming, presents OpenMP more than appropriately, from the perspective of high performance computing, which traditionally has provided most (if not all) the parallel software development ...
Fernando Gustavo Tinetti
doaj  

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source