Results 51 to 60 of about 404,625 (284)

Coupling landscapes and river flows to restore highly modified rivers

Water Resources Research, 2019
Modifications to landscapes and flow regimes of rivers have altered the function, biodiversity, and productivity of freshwater ecosystems globally. Reestablishing geomorphological and hydrological conditions necessary to sustain ecosystems is a central ...
A. A. Whipple, J. H. Viers
doaj   +1 more source

Combining multiomics and drug perturbation profiles to identify muscle-specific treatments for spinal muscular atrophy

JCI Insight, 2021
Spinal muscular atrophy (SMA) is a neuromuscular disorder caused by loss of survival motor neuron (SMN) protein. While SMN restoration therapies are beneficial, they are not a cure.
Katharina E. Meijboom, Viola Volpato, Jimena Monzón-Sandoval, Joseph M. Hoolachan, Suzan M. Hammond, Frank Abendroth, Olivier G. de Jong, Gareth Hazell, Nina Ahlskog, Matthew J.A. Wood, Caleb Webber, Melissa Bowerman   +11 more
doaj   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Process-Based Ecological River Restoration: Visualizing Three-Dimensional Connectivity and Dynamic Vectors to Recover Lost Linkages

Ecology and Society, 2006
Human impacts to aquatic ecosystems often involve changes in hydrologic connectivity and flow regime. Drawing upon examples in the literature and from our experience, we developed conceptual models and used simple bivariate plots to visualize human ...
G. Mathias. Kondolf, Andrew J. Boulton, Scott O'Daniel, Geoffrey C. Poole, Frank J. Rahel, Emily H. Stanley, Ellen Wohl, Asa Bång, Julia Carlstrom, Chiara Cristoni, Harald Huber, Saija Koljonen, Pauliina Louhi, Keigo Nakamura   +13 more
doaj   +1 more source

Oyster Bed Mapping in the Great Bay Estuary, 2012-2013 [PDF]

, 2013
Six major oyster beds (reefs) in New Hampshire are mapped periodically to assess wild oyster populations in the Great Bay Estuary. Data on the spatial extent of the beds are combined with density and other measures to estimate the abundances of live ...
Grizzle, Raymond E., Ward, Krystin M.
core   +2 more sources

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Structuring supply chains of native plant material of wild and local provenance in France: A contribution to ecological restoration and Nature-based solutions

Nature-Based Solutions, 2022
European policies aim to simultaneously address the biodiversity and climate crises, partially through the implementation of nature-based solutions (NbS).
Stéphane Rivière, Damien Provendier, Sandra Malaval, Baptiste Sanson, Johan Gourvil, Arnaud Albert, Jérôme Millet   +6 more
doaj   +1 more source

Pickering Brook Salt Marsh Restoration - Phase II [PDF]

, 2005
In the early 1900’s, the majority of coastal salt marshes in New England were ditched as part of an aggressive mosquito control program. In an attempt to eradicate mosquito-breeding habitat, open water areas were drained by a series of ditches excavated ...
Reilly, Patti
core   +1 more source

Chiral Condensate in Holographic QCD with Baryon Density

, 2012
We consider the chiral condensate in the baryonic dense medium using the generalized Sakai-Sugimoto model. It is defined as the vacuum expectation value of open Wilson line that is proposed to be calculated by use of the area of world-sheet instanton. We
A Dhar, E Witten, G Brown, H Hata, JM Maldacena, JM Maldacena, K Hashimoto, K Hashimoto, K Peeters, K-Y Kim, K-Y Kim, M Rho, O Aharony, O Aharony, O Bergman, O Bergman, R Casero, S Nakamura, S Seki, S Seki, Sang-Jin Sin, Shigenori Seki, T Sakai, T Sakai, Y Seo   +24 more
core   +2 more sources

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source