Results 61 to 70 of about 1,785,585 (297)

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Process-Based Ecological River Restoration: Visualizing Three-Dimensional Connectivity and Dynamic Vectors to Recover Lost Linkages

Ecology and Society, 2006
Human impacts to aquatic ecosystems often involve changes in hydrologic connectivity and flow regime. Drawing upon examples in the literature and from our experience, we developed conceptual models and used simple bivariate plots to visualize human ...
G. Mathias. Kondolf, Andrew J. Boulton, Scott O'Daniel, Geoffrey C. Poole, Frank J. Rahel, Emily H. Stanley, Ellen Wohl, Asa Bång, Julia Carlstrom, Chiara Cristoni, Harald Huber, Saija Koljonen, Pauliina Louhi, Keigo Nakamura   +13 more
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Accurate reactive power sharing and voltage-frequency recovery strategy for multiple grid-forming converters based on consensus algorithms

Energy Reports
In isolated AC microgrids, parallel multi-inverter systems face challenges in precisely distributing reactive power output from distributed generation (DG) units due to varying DG parameters and mismatched line impedances.
Xu Jiang, Jun Leng, Shaojie Qu, Zhonghui Gao, Weifeng Zhao, Jianhui Meng   +5 more
doaj   +1 more source

A dilemma resolved? Towards a revised philosophy of conservation education [PDF]

, 2002
The guidelines for conservation education agreed by the European Confederation of Conservator-restorers’ Organisations’ state that “The only reasonable way of training in conservation/restoration is full time at university level or at an equivalent level,
Schiro, Joseph, Conference on Scientific Aspects of Conservation, Cannataci, Joseph A., Caruana, Martina, Malta Centre for Restoration (MCR)   +4 more
core  

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

A Dual-Branch Parallel Network for Speech Enhancement and Restoration

Computer Speech & Language
Accepted for publication in Computer Speech & Language (2026).
Da-Hee Yang, Dail Kim, Joon-Hyuk Chang, Jeonghwan Choi, Han-Gil Moon   +4 more
openaire   +2 more sources

Parallel computational fluid dynamics : implementations and results using parallel computers : proceedings of the Parallel CFD '95 Conference, Pasadena, CA, U.S.A., 26-29 June, 1995 /

, 1996
Parallel Computational Fluid Dynamics(CFD) is an internationally recognised fast-growing field. Since 1989, the number of participants attending Parallel CFD Conferences has doubled. In order to keep track of current global developments, the Parallel CFD
Parallel CFD Conference(1995 :Pasadena, Calif.), Ecer, Akin.   +1 more
core  

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source