Results 51 to 60 of about 1,770,360 (244)

Combining multiomics and drug perturbation profiles to identify muscle-specific treatments for spinal muscular atrophy

JCI Insight, 2021
Spinal muscular atrophy (SMA) is a neuromuscular disorder caused by loss of survival motor neuron (SMN) protein. While SMN restoration therapies are beneficial, they are not a cure.
Katharina E. Meijboom, Viola Volpato, Jimena Monzón-Sandoval, Joseph M. Hoolachan, Suzan M. Hammond, Frank Abendroth, Olivier G. de Jong, Gareth Hazell, Nina Ahlskog, Matthew J.A. Wood, Caleb Webber, Melissa Bowerman   +11 more
doaj   +1 more source

Comparing the paths of Hedgehog release in artificial and natural settings

FEBS Letters, EarlyView.
Hh morphogens require solubilization factors to overcome their tight association with the plasma membrane and signal to distant cells, but the precise functions of these factors are controversial. Here, we use published in vivo observations as the most relevant evidence to test their suggested functions and discuss contradictions and gaps between in ...
Janna Puschmann, Kay Grobe
wiley   +1 more source

Deep Equilibrium Diffusion Restoration with Parallel Sampling

2024 IEEE/CVF Conference on Computer Vision and Pattern Recognition (CVPR)
2024 IEEE/CVF Conference on Computer Vision and Pattern Recognition (CVPR)
Cao, Jiezhang; id_orcid0000-0002-0050-4714, Shi, Yue, Zhang, Kai; id_orcid0000-0002-6319-3722, Zhang, Yulun; id_orcid0000-0002-2288-5079, Timofte, Radu, Van Gool, Luc   +5 more
openaire   +5 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

PARALLEL ELECTRIC-FIELD IN FLUX RESTORATION DURING ULTRAFILTRATION

, 2015
Ultrafiltration membrane permeability may be restored by applying an electric field parallel to the plane of the membrane in the feed compartment of ultrafiltration cells. Two different electrode arrangements are described.
GALEMBECK, F, ZANIQUELLI, MED, SILVA, M
core   +1 more source

Restoration ecophysiology: an ecophysiological approach to improve restoration strategies and outcomes in severely disturbed landscapes [Elektronisk resurs]

, 2022
As human activities destroy and degrade the world's ecosystems at unprecedented scales, there is a growing need for evidence-based methods for ecological restoration if we are to preserve biodiversity and ecosystem services.
Yong, Jean W.H,, Sveriges lantbruksuniversitet.   +1 more
core   +1 more source

Process-Based Ecological River Restoration: Visualizing Three-Dimensional Connectivity and Dynamic Vectors to Recover Lost Linkages

Ecology and Society, 2006
Human impacts to aquatic ecosystems often involve changes in hydrologic connectivity and flow regime. Drawing upon examples in the literature and from our experience, we developed conceptual models and used simple bivariate plots to visualize human ...
G. Mathias. Kondolf, Andrew J. Boulton, Scott O'Daniel, Geoffrey C. Poole, Frank J. Rahel, Emily H. Stanley, Ellen Wohl, Asa Bång, Julia Carlstrom, Chiara Cristoni, Harald Huber, Saija Koljonen, Pauliina Louhi, Keigo Nakamura   +13 more
doaj   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

A role for eIF5A in translational control of stress‐inducible proteins in multiple myeloma cell lines

Molecular Oncology, EarlyView.
Loss of eIF5A rewires thapsigargin‐mediated endoplasmic reticulum stress responses in multiple myeloma cells by selective translation of mRNA transcripts, consequently dampening thapsigargin‐induced unfolded protein response (UPR) activation and shifting the balance from induction of apoptosis toward cell survival and proliferation.
Demi Both, Ingrid A. M. Derks, Raphaël Vanleyssem, Marine Leclercq, Najla El Hachem, Pierre Close, Eric Eldering, Marco Vincent Haselager   +7 more
wiley   +1 more source

Accurate reactive power sharing and voltage-frequency recovery strategy for multiple grid-forming converters based on consensus algorithms

Energy Reports
In isolated AC microgrids, parallel multi-inverter systems face challenges in precisely distributing reactive power output from distributed generation (DG) units due to varying DG parameters and mismatched line impedances.
Xu Jiang, Jun Leng, Shaojie Qu, Zhonghui Gao, Weifeng Zhao, Jianhui Meng   +5 more
doaj   +1 more source