Results 81 to 90 of about 404,625 (284)

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

Conservation-Restoration paradigm shift after disaster: the Graphic Documents case study

Conservar Património, 2017
With this paper we draw attention to the role of the disaster, leading to profound changes, to the paradigm shift in the intervention of conservation and restoration of graphic documents, based on the study of case studies from the two main disaster ...
Maria da Conceição Lopes Casanova
doaj   +1 more source

Restoration of Degraded Images Using Pupil-Size Diversity Technology With Stochastic Parallel Gradient Descent Algorithm

IEEE Photonics Journal, 2016
The performance of imaging systems is inevitably degraded by aberrations of optical systems. Furthermore, images detected by long-distance imaging schemes also suffer blurring induced by atmospheric turbulence.
Zongliang Xie, Haotong Ma, Bo Qi, Ge Ren, Yufeng Tan, Bi He, Hengliang Zeng, Chuan Jiang   +7 more
doaj   +1 more source

The Aging Blood: Cellular Origins, Circulating Drivers, and Therapeutic Potential

Aging and Cancer, EarlyView.
As a conduit linking all organs, the blood system both reflects and actively drives systemic aging. This review highlights how circulating pro‐aging and antiaging factors and age‐associated hematopoietic stem cell dysfunction contribute to immunosenescence and multi‐organ decline, positioning the hematopoietic system as a target for aging intervention.
Hanqing He, Jianwei Wang
wiley   +1 more source

Power System Restoration Planning Strategy Based on Optimal Energizing Time of Sectionalizing Islands

Energies, 2018
Common power system restoration planning strategy is based on a ‘build up’ approach, where a blackout system is sectionalized among several islands for parallel restoration prior to resynchronization.
Dian Najihah Abu Talib, Hazlie Mokhlis, Mohamad Sofian Abu Talip, Kanendra Naidu, Hadi Suyono   +4 more
doaj   +1 more source

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source

THEIOI AUTOKRATORES. A Fragment of an Honorary Inscription from the Smintheion

Gephyra
This article presents a fragmentary inscribed slab discovered in the sanctuary of Apollo Smintheus in 2009. The author proposes a restoration for this fragmentary inscription in the article, by comparing it with parallel epigraphic examples from Asia ...
Tolga Özhan
doaj   +1 more source

The MMP‐9/TIMP‐1 Ratio and Concentrations of Osteopontin Are Elevated in Cerebrospinal Fluid of People With Multiple Sclerosis and Decrease After Autologous Hematopoietic Stem Cell Transplantation

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives To evaluate the utility of cerebrospinal fluid (CSF) biomarkers—matrix metalloproteinase‐9 (MMP‐9), tissue inhibitor of metalloproteinases‐1 (TIMP‐1), the MMP‐9/TIMP‐1 ratio, and osteopontin (OPN)—as indicators of blood–brain barrier (BBB) integrity and disease activity in people with relapsing–remitting multiple sclerosis (pwMS ...
Ivan Pavlovic, Ida Erngren, Kim Kultima, Anders Larsson, Malin Müller, Anna Wiberg, Joachim Burman   +6 more
wiley   +1 more source

Management of International Cooperation of Japanese and German Universities – Historical Background and Actual Experiences – [PDF]

Cooperation of universities is increasingly needed in order to educate productive and team-oriented young scholars at Western and Far Eastern Universities.
Karl-Heinz SCHMIDT
core  

Exploratory Analysis of ELP1 Expression in Whole Blood From Patients With Familial Dysautonomia

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Familial dysautonomia (FD) is a hereditary neurodevelopmental disorder caused by aberrant splicing of the ELP1 gene, leading to a tissue‐specific reduction in ELP1 protein expression. Preclinical models indicate that increasing ELP1 levels can mitigate disease manifestations.
Alejandra González‐Duarte, Lucy Norcliffe‐Kaufmann, Maria Luisa Cotrina, Zenith Khan, Kaia Dalamo, Patricio Millar Vernetti, Matthew Lawless, Elisabetta Morini, Monica Salani, Marla Weetall, Jana Narasimhan, Agostino G. Rocha, Susan A. Slaugenhaupt, Horacio Kaufmann   +13 more
wiley   +1 more source