Results 61 to 70 of about 234,995 (219)

The role of microglial inflammasome activation in pyroptotic cell death following penetrating traumatic brain injury

Journal of Neuroinflammation, 2019
Background Traumatic brain injury remains a significant cause of death and disability in the USA. Currently, there are no effective therapies to mitigate disability except for surgical interventions necessitating a need for continued research into ...
Stephanie W. Lee, Juan Pablo de Rivero Vaccari, Jessie S. Truettner, W. Dalton Dietrich, Robert W. Keane   +4 more
doaj   +1 more source

β‐Adducin Restrains PLA2G4A‐Dependent Lysosomal Membrane Permeabilization and Neuronal Death in Ischemic Stroke

Advanced Science, EarlyView.
This study identifies β‐adducin as a regulator of lysosomal integrity in ischemic neurons. Ischemia‐associated FTO loss increases m6A modification and destabilizes Add2 mRNA, reducing β‐adducin expression and promoting PLA2G4A accumulation at lysosomes.
Hui‐qin Li, Pin‐yi Liu, Dan Wu, Fei‐yu Ma, Yi Bai, Sheng‐nan Xia, Hai‐yan Yang, Xin‐yu Bao, Yun Xu, Xiang Cao   +9 more
wiley   +1 more source

Inhibition of microglia priming by NLRP3 reduces the impact of early life stress and mild TBI

Journal of Neuroinflammation
Although most patients with mild traumatic brain injury (mTBI) experience rapid recovery, some report persistent chronic symptoms such as cognitive dysfunction. One risk factor for prolonged recovery after mTBI is early life stress (ELS). We hypothesized
Fabiola Placeres-Uray, Aditi S. Gorthy, Maria Dominguez Torres, Coleen M. Atkins   +3 more
doaj   +1 more source

Targeted siRNA delivery reduces nitric oxide mediated cell death after spinal cord injury

Journal of Nanobiotechnology, 2017
Background Traumatic spinal cord injury (SCI) includes the primary insult as well as a sequela of biochemical and cellular cascades that amplifies the initial injury.
Wen Gao, Jianming Li
doaj   +1 more source

Gut Microbiota‐Derived Indole‐3‐Acetaldehyde Contributes to the Disease‐Alleviating Effects of Kurarinone in Experimental Autoimmune Encephalomyelitis

Advanced Science, EarlyView.
Kurarinone ameliorates EAE via the gut microbiota‐indole‐3‐acetaldehyde‐AhR axis. Kurarinone reshapes gut microbiota and increases Akkermansia muciniphila, which promotes intestinal indole‐3‐acetaldehyde production. Indole‐3‐acetaldehyde crosses the intestinal barrier, activates AhR in CD4+ T cells, upregulates SOCS1/3, inhibits JAK2 and STAT3/4 ...
Xinyan Han, Jiaqi Ding, Zonghao Pan, Weitai He, Xue Kang, Cong Zhao, Yi Li, Di Wu, Hongzeng Li, Kaixi Ren, Jiaji Lin, Jun Guo   +11 more
wiley   +1 more source

Temporal and Severity-Dependent Alterations in Plasma Extracellular Vesicle Profiles Following Spinal Cord Injury

Cells
Spinal cord injury (SCI) triggers both local and systemic pathological responses that evolve over time and differ with injury severity. Small extracellular vesicles (sEVs), known mediators of intercellular communication, may serve as biomarkers ...
Jamie Cooper, Scott Tait Airey, Eric Patino, Theo Andriot, Mousumi Ghosh, Damien D. Pearse   +5 more
doaj   +1 more source

Activation of Brainstem Neurons During Mesencephalic Locomotor Region-Evoked Locomotion in the Cat

Frontiers in Systems Neuroscience, 2019
The distribution of locomotor-activated neurons in the brainstem of the cat was studied by c-Fos immunohistochemistry in combination with antibody-based cellular phenotyping following electrical stimulation of the mesencephalic locomotor region (MLR ...
Ioan Opris, Xiaohong Dai, Dawn M. G. Johnson, Francisco J. Sanchez, Luz M. Villamil, Songtao Xie, Cecelia R. Lee-Hauser, Stephano Chang, Larry M. Jordan, Brian R. Noga   +9 more
doaj   +1 more source

A Biomimetic PLK1 Nanodelivery System Promotes Migrasome‐Mediated Mitocytosis to Restore Efferocytosis and Functional Recovery After Spinal Cord Injury

Advanced Science, EarlyView.
MM‐NPs@PLK1 are formed by encapsulating PLK1 plasmids within CBP5 and coating the nanocomplexes with macrophage membranes. After macrophage‐associated uptake, the NPs@PLK1 enter the cytoplasm and release the PLK1‐encoding plasmid in response to elevated intracellular ROS levels.
Zhenxin Hu, Haoli Wang, Jing Huang, Junhua Zhou, Jialong Hou, Hanwei Miao, Huixin Tan, Yining Wang, Hao Hu, Na Li, Pengcheng Qiu, Hongyu Zhang, Da He, Qingqing Wang   +13 more
wiley   +1 more source

Comparative Analysis of Cardiac Puncture and Perfusate Blood Collection for Murine Extracellular Vesicle Isolation

Methods and Protocols
Reliable characterization of circulating extracellular vesicles (EVs) in rodents may be significantly influenced by how blood is collected, yet systematic comparisons of commonly used sampling methods remain limited.
Jamie Cooper, Scott Tait Airey, Eric Patino, Theo Andriot, Mousumi Ghosh, Damien D. Pearse   +5 more
doaj   +1 more source

Astrocytic Ketogenesis Protects Central Nervous System Injury via CPT1A Stabilization and Epigenetic Regulation

Advanced Science, EarlyView.
A distinct astrocyte subpopulation, enriched at the lesion border, drives CNS repair through enhanced ketone body metabolism. This process promotes neuronal survival and axonal sparing via CPT1A stabilization and H3K9bhb‐dependent epigenetic reprogramming, positioning astrocytic ketogenesis as a promising therapeutic target for tissue regeneration ...
Dishui Pan, Haoming Shu, Rui Gao, Yilong Ren, Wu Ye, Xuhui Ge, Yao Gu, Yufeng Zhu, Xiaokun Wang, Honglin Teng, Xuhui Zhou, Wei Liu, Yang Gao, Jianquan Zhao, Weihua Cai   +14 more
wiley   +1 more source