Results 71 to 80 of about 234,995 (219)

Article Commentary: Transplants of Neuronal Cells Bioengineered to Synthesize GABA Alleviate Chronic Neuropathic Pain

Cell Transplantation, 1999
The use of cell lines utilized as biologic “minipumps” to provide antinociceptive molecules, such as GABA, in animal models of pain is a newly developing area in transplantation biology.
M. J. Eaton Ph.D., J. A. Plunkett, M. A. Martinez, T. Lopez, S. Karmally, P. Cejas, S. R. Whittemore   +6 more
doaj   +1 more source

Targeting Mitochondrial Redox Signaling Promotes Neuroregeneration and Functional Recovery in a Multiple Sclerosis Model

Advanced Science, EarlyView.
Modulation of mitochondrial redox signaling by furapyrrodole activates CYB5R3 and suppresses Notch signaling, unlocking the regenerative potential of endogenous neural progenitor cells. This approach promotes neurogenesis, oligodendrogenesis, and remyelination, thereby improving neuronal function in a mouse model of multiple sclerosis and identifying ...
Yuki Narushima, Joshua Saylor, Shun Saito, Jinyan Zhou, Haruka Kawano, Shehata Anwar, Haruki Oba, Rachel Huezo, Miyu Okano, Haruki Matsuda, Makoto Kawatani, Kaori Honda, Hiroyuki Osada, Yuta Kikuchi, Masahito Ohue, Masami Ishibashi, Takayoshi Arai, Makoto Inoue, Midori A. Arai   +18 more
wiley   +1 more source

Enhanced Transcriptional Activity and Mitochondrial Localization of STAT3 Co-induce Axon Regrowth in the Adult Central Nervous System

Cell Reports, 2016
Signal transducer and activator of transcription 3 (STAT3) is a transcription factor central to axon regrowth with an enigmatic ability to act in different subcellular regions independently of its transcriptional roles.
Xueting Luo, Marcio Ribeiro, Eric R. Bray, Do-Hun Lee, Benjamin J. Yungher, Saloni T. Mehta, Kinjal A. Thakor, Francisca Diaz, Jae K. Lee, Carlos T. Moraes, John L. Bixby, Vance P. Lemmon, Kevin K. Park   +12 more
doaj   +1 more source

Fluorescent Hydrogel‐Based Strain Sensor With Machine Learning‐Augmented Performance

Advanced Intelligent Discovery, EarlyView.
Fluorescent hydrogel strain sensor based on carbon quantum dots enabling optical readout of deformation through strain‐dependent emission changes, coupled with Random Forest analysis to capture nonlinear fluorescence‐concentration relationships and identify optimal sensing conditions. Hydrogels are ideal matrices for bio‐integrated wearable sensors due
Tailai Chen, Tianlong Liu, Chao Lu, Rimsha Malik, Jin Zhang   +4 more
wiley   +1 more source

An Active Knee–Ankle–Foot Orthosis With Torque‐Dense, Low‐Impedance Knee Actuation

Advanced Intelligent Systems, EarlyView.
This article presents the simulation, design, and clinical validation of a robotic active KAFO with torque‐sensitive actuation. By passively and continuously adapting the transmission ratio in response to the knee torque, the torque‐sensitive actuator overcomes the tradeoff between torque, weight, and impedance observed in conventional robot actuators,
Brendon Ortolano, Kai Pruyn, Rosemarie Murray, Lukas Gabert, Tommaso Lenzi   +4 more
wiley   +1 more source

Accounting for animal health in efficiency analysis: An application to Swedish dairy farms

American Journal of Agricultural Economics, EarlyView.
Abstract Poor animal health is a central concern in modern livestock production. Despite the necessity to incorporate animal health in efficiency analysis, the theoretical and empirical developments are limited on this subject. This article appropriately characterizes the axiomatic properties of animal health within a production framework.
Frederic Ang, Enoch Owusu‐Sekyere, Karin Alvåsen, Helena Hansson   +3 more
wiley   +1 more source

The psychosocial toll of Dublin III on asylum seekers in the Netherlands

American Journal of Community Psychology, EarlyView.
Abstract The Dublin III Regulation determines which EU Member State is responsible for examining asylum claims, but its implementation carries significant consequences for those subjected to it. This study examines how Dublin III, as implemented in the Netherlands, affects asylum seekers' psychosocial wellbeing using Silove′s Adaptation and Development
Imen El Amouri
wiley   +1 more source

Alzheimer’s Disease Leads to Chronic Pathological Changes and Inflammasome Signaling in an Animal Model of Traumatic Brain Injury

Cells
Traumatic brain injury (TBI) is a significant public health concern, often resulting in long-term impairments. TBI is also a known risk factor for Alzheimer’s disease (AD), with both conditions sharing features such as inflammasome dysregulation ...
Erika d. l. R. M. Cabrera Ranaldi, Nathan H. Johnson, Andrew P. Sawaya, Jhianyn R. Herrera, Nadine Ahmed Kerr, Helen M. Bramlett, Robert W. Keane, W. Dalton Dietrich, Juan Pablo de Rivero Vaccari   +8 more
doaj   +1 more source

High Diagnosis Rate for Nonimmune Hydrops Fetalis With Prenatal Clinical Genome: Expanded Results From the Hydrops‐Yielding Diagnostic Results of Prenatal Sequencing (HYDROPS) Study

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Nonimmune hydrops fetalis (NIHF) is characterized by abnormal fluid accumulation in ≥ 2 fetal compartments and may be genetic. The incremental diagnostic yield of prenatal exome sequencing (ES) for NIHF following a negative standard workup was previously explored on 22 cases.
Stephanie M. Rice, Mona M. Makhamreh, Sascha Wodoslawsky, Mariella Toro, Elizabeth Critchlow, Brandy Firman, Ruby Liu, Babi Ramesh Nallamilli, Madhuri Hegde, Seth I. Berger, Huda B. Al‐Kouatly   +10 more
wiley   +1 more source

IC100 blocks inflammasome activation induced by α-synuclein aggregates and ASC specks

npj Parkinson's Disease
Parkinson’s disease (PD) is associated with chronic sterile inflammation and persistent inflammasome activation involving α-synuclein and ASC protein aggregates, but the underlying mechanisms of the neuroinflammatory response remain unclear.
Brianna Cyr, Regina T. Vontell, Roey Hadad, Juan Pablo de Rivero Vaccari, Robert W. Keane   +4 more
doaj   +1 more source